Calcium near the release site is essential for basal ACh release in Xenopus

被引：9
|
作者：
Li, Ruxin [1 ]
Lei, Qi [1 ]
Song, Ge [1 ]
He, Xiangping [1 ]
Xie, Zuoping [1 ]
机构：
[1] Tsinghua Univ, Dept Biol Sci & Biotechnol, Natl State Key Lab Biomembrane & Membrane Biotech, Beijing 100084, Peoples R China
来源：
CELL BIOLOGY INTERNATIONAL | 2008年 / 32卷 / 09期
关键词：
Calcium; Basal neurotransmitter release; Spontaneous synaptic currents;
D O I：
10.1016/j.cellbi.2008.05.001
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Extracellular calcium is essential for neurotransmitter release, but the detailed mechanism by which Ca2+ regulates basal synaptic release has not yet been fully explored. In this study, calcium imaging and the whole-cell patch-clamp technique were used to investigate the role of Ca2+ in basal acetylcholine (ACh) release in the Xenopus neuromuscular junction and in isolated myocytes exogenously loaded with ACh. Carried out in normal and Ca2+-free extracellular solution, the results indicate that Ca2+ near the release site is essential for basal neurotransmitter release. (C) 2008 International Federation for Cell Biology. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：1136 / 1142
页数：7
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