RETRACTED: A porous Co(II)-MOF for selective C2H2/CO2 separation and treatment activity on virus-induced COPD via reducing tlr3 gene expression (Retracted article. See MAY, 2023)

A new metal-organic framework (MOF) formulated as {[Co(L)]center dot 4H(2)O center dot 2CH(3)CN}(n)(1) has been prepared by solvothermal reaction of Co(NO3)(2)center dot 6H(2)O with a bifunctional ligand 5-(3,5-di-pyridin-4-yl-[1,2,4]triazol-1-ylmethyl)-isophthalic acid (H2L) in a mixed solvent of DMA/H2O/CH3CN (DMA = N,N-dimethylacetamide). The microporous MOF1has accessible alkaline sites which could be applied for the separation of C(2)H(2)from a gas mixture of C2H2/CO2. The adsorption capacity of C(2)H(2)and selectivity of C2H2/CO(2)are equal to those of reference materials, which make the material hopeful to become a significant C2H2/CO(2)separation material. In biological functional study, the treatment activity of the compound on chronic obstructive pulmonary disease (COPD) was induced byinfluenza Avirus infection. First, the relative expression of thetlr3gene on the alveolar macrophages was measured with real time reverse transcription polymerase chain reaction (RT-PCR). The Enzyme Linked Immune Sorbent Assay (ELISA) detection was used for the evaluation of the inflammatory cytokines releasing after compound treatment against COPD. Finally, molecular docking was performed to predict the potential binding modes of the complex to TLR3 protein.