With the aim of identifying genes involved in cartilage differentiation, we have used a subtractive hybridization strategy with cDNAs from a chondrocytic cell line (MC615) and mRNAs from a mesenchymal precursor cell line (10T1/2). We have isolated a cDNA clone representing a novel mouse gene. The predicted 368-amino acid protein, designated ZF-12, contains four C2H2-type zinc finger motifs and one region homologous to the LeR domain, a finger-associated structural domain. ZF-12 mRNAs are expressed during embryonic development and in different organs in adult, including rib cartilage. These data suggest that ZF-12, might play an important role not only in cartilage differentiation, but also in basic cellular processes. (C) 1999 Elsevier Science B.V. All rights reserved.
机构:W China Univ Med Sci, Affiliated Hosp, Dept Med Genet, Chengdu 610041, Sichuan, Peoples R China
Wu, H
Zhang, SH
论文数: 0引用数: 0
h-index: 0
机构:
W China Univ Med Sci, Affiliated Hosp, Dept Med Genet, Chengdu 610041, Sichuan, Peoples R ChinaW China Univ Med Sci, Affiliated Hosp, Dept Med Genet, Chengdu 610041, Sichuan, Peoples R China
Zhang, SH
Qiu, WM
论文数: 0引用数: 0
h-index: 0
机构:W China Univ Med Sci, Affiliated Hosp, Dept Med Genet, Chengdu 610041, Sichuan, Peoples R China
Qiu, WM
Zhang, G
论文数: 0引用数: 0
h-index: 0
机构:W China Univ Med Sci, Affiliated Hosp, Dept Med Genet, Chengdu 610041, Sichuan, Peoples R China
Zhang, G
Xia, QJ
论文数: 0引用数: 0
h-index: 0
机构:W China Univ Med Sci, Affiliated Hosp, Dept Med Genet, Chengdu 610041, Sichuan, Peoples R China
Xia, QJ
Xiao, CY
论文数: 0引用数: 0
h-index: 0
机构:W China Univ Med Sci, Affiliated Hosp, Dept Med Genet, Chengdu 610041, Sichuan, Peoples R China
Xiao, CY
Huang, XL
论文数: 0引用数: 0
h-index: 0
机构:W China Univ Med Sci, Affiliated Hosp, Dept Med Genet, Chengdu 610041, Sichuan, Peoples R China
Huang, XL
Huang, MK
论文数: 0引用数: 0
h-index: 0
机构:W China Univ Med Sci, Affiliated Hosp, Dept Med Genet, Chengdu 610041, Sichuan, Peoples R China
Huang, MK
Agen, P
论文数: 0引用数: 0
h-index: 0
机构:W China Univ Med Sci, Affiliated Hosp, Dept Med Genet, Chengdu 610041, Sichuan, Peoples R China
Agen, P
Fan, TY
论文数: 0引用数: 0
h-index: 0
机构:W China Univ Med Sci, Affiliated Hosp, Dept Med Genet, Chengdu 610041, Sichuan, Peoples R China
Fan, TY
Yang, J
论文数: 0引用数: 0
h-index: 0
机构:W China Univ Med Sci, Affiliated Hosp, Dept Med Genet, Chengdu 610041, Sichuan, Peoples R China
Yang, J
Milunsky, A
论文数: 0引用数: 0
h-index: 0
机构:W China Univ Med Sci, Affiliated Hosp, Dept Med Genet, Chengdu 610041, Sichuan, Peoples R China
Milunsky, A
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION,
2001,
1518
(1-2):
: 190
-
193