Pd(II)-Catalyzed Ph2(O)P-Directed C-H Olefination toward Phosphine-Alkene Ligands

被引：88

作者：

Wang, Hong-Li ^{[1
]}

Hu, Rong-Bin ^{[1
]}

Zhang, Heng ^{[1
]}

Zhou, An-Xi ^{[1
]}

Yang, Shang-Dong ^{[1
,2
]}

机构：

[1] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

[2] Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 20期

关键词：

CATALYZED ASYMMETRIC 1,4-ADDITION; ARYL HYDROGEN PHOSPHATES; DIRECTING GROUP; BOND FORMATION; ACTIVATION; ALKENYLATION; RHODIUM(III); C(SP(2))-H; ARYLATION; VERSATILE;

D O I：

10.1021/ol402577p

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The Pd(II)-catalyzed Ph-2(O)P-directed C-H olefination to synthesize alkene-phosphine compounds is reported. In contrast to previous examples of various directing groups that guide selective C-H activation, the Ph-2(O)P group not only acts as the directing group but also serves to construct the alkene-phosphine ligands. The monoprotected amino acid (MPAA) ligand Ac-Leu-OH is found to promote this reaction in a significant manner.

引用

页码：5302 / 5305

页数：4

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