Oxidation of d-α-tocopherol in aqueous solution.: Formation of colored products

被引：0
|
作者：
Nagata, Y
Miyamoto, C
Matsushima, Y
Matsumoto, S
机构：
[1] Kyoritsu Coll Pharm, Minato Ku, Tokyo 1058512, Japan
[2] Tokyo Metropolitan Inst Gerontol, Itabashi Ku, Tokyo 1730015, Japan
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 1999年 / 47卷 / 07期
关键词：
d-alpha-tocopherol; 5-formyl-7,8-dimethyltocol; 7-formyl-5,8-dimethyltocol; alpha-tocoquinone; sodium deoxycholate; sodium cholate;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
An aqueous solution of d-alpha-tocopherol solubilized with sodium deoxycholate became colored on standing, probably due to air oxidation. 5-Formyl-7,8-dimethyltocol (1) and 7-formyl-5,8-dimethyltocol (2) were isolated from the solution and concluded to be responsible for the coloration. In oxidation of aqueous solutions of d-alpha-tocopherol, the time course of formation of products was followed by analytical HPLC. The main oxidation product was 1 in solutions solubilized with sodium deoxycholate and sodium cholate, whereas alpha-tocoquinone was the main product in those solubilized with 2,6-di-O-methyl-beta-cyclodextrin.
引用
收藏
页码：923 / 927
页数：5
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