Toxicity of superparamagnetic iron oxide nanoparticles: Research strategies and implications for nanomedicine

被引：38
|
作者：
Li Lei [1 ]
Jiang Ling-Ling [1 ]
Zeng Yun [1 ,2 ]
Liu Gang [1 ]
机构：
[1] Xiamen Univ, Sch Publ Hlth, Ctr Mol Imaging & Translat Med, Xiamen 361102, Peoples R China
[2] North Sichuan Med Coll, Sichuan Key Lab Med Imaging, Nanchong 637007, Peoples R China
来源：
CHINESE PHYSICS B | 2013年 / 22卷 / 12期
基金：
中国国家自然科学基金;
关键词：
superparamagnetic iron oxide nanoparticle; nanotoxicity; cytotoxicity; oxidative stress; reactive oxygen species; MAGNETIC NANOPARTICLES; IN-VIVO; OXIDATIVE STRESS; DRUG-DELIVERY; STEM-CELLS; BIOMEDICAL APPLICATIONS; TISSUE DISTRIBUTION; TARGETED DELIVERY; PROSTATE-CANCER; CONTRAST AGENT;
D O I：
10.1088/1674-1056/22/12/127503
中图分类号：
O4 [物理学];
学科分类号：
0702 ;
摘要：
Superparamagnetic iron oxide nanoparticles (SPIONs) are one of the most versatile and safe nanoparticles in a wide variety of biomedical applications. In the past decades, considerable efforts have been made to investigate the potential adverse biological effects and safety issues associated with SPIONs, which is essential for the development of next-generation SPIONs and for continued progress in translational research. In this mini review, we summarize recent developments in toxicity studies on SPIONs, focusing on the relationship between the physicochemical properties of SPIONs and their induced toxic biological responses for a better toxicological understanding of SPIONs.
引用
收藏
页数：10
相关论文
共 50 条
  • [21] Nitric oxide donor superparamagnetic iron oxide nanoparticles
    Molina, Miguel M.
    Seabra, Amedea B.
    de Oliveira, Marcelo G.
    Itri, Rosangela
    Haddad, Paula S.
    MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2013, 33 (02): : 746 - 751
  • [22] BIOCOMPATIBLE, SUPERPARAMAGNETIC, FLAME SYNTHESIZED IRON OXIDE NANOPARTICLES: CELLULAR UPTAKE AND TOXICITY STUDIES
    Buyukhatipoglu, Kivilcirn
    Miller, Tiffany A.
    Clyne, Alisa Morss
    PROCEEDINGS OF THE ASME INTERNATIONAL MECHANICAL ENGINEERING CONGRESS AND EXPOSITION 2008, VOL 2, 2009, : 245 - 248
  • [23] Persistent Photomagnetism in Superparamagnetic Iron Oxide Nanoparticles
    He, Shuai
    DuChene, Joseph S.
    Qiu, Jingjing
    Puretzky, Alexander A.
    Gai, Zheng
    Wei, Wei David
    ADVANCED ELECTRONIC MATERIALS, 2018, 4 (07):
  • [24] Biological Properties of Superparamagnetic Iron Oxide Nanoparticles
    Lindemann, Antje
    Pries, Ralph
    Luedtke-Buzug, Kerstin
    Wollenberg, Barbara
    IEEE TRANSACTIONS ON MAGNETICS, 2015, 51 (02) : 5200204
  • [25] Superparamagnetic Iron Oxide Nanoparticles in Musculoskeletal Biology
    Iyer, Shama R.
    Xu, Su
    Stains, Joseph P.
    Bennett, Craig H.
    Lovering, Richard M.
    TISSUE ENGINEERING PART B-REVIEWS, 2017, 23 (04) : 373 - 385
  • [26] Washing effect on superparamagnetic iron oxide nanoparticles
    Mireles, Laura-Karina
    Sacher, Edward
    Yahia, L'Hocine
    Laurent, Sophie
    Stanicki, Dimitri
    DATA IN BRIEF, 2016, 7 : 1296 - 1301
  • [27] Protective coating of superparamagnetic iron oxide nanoparticles
    Kim, DK
    Mikhaylova, M
    Zhang, Y
    Muhammed, M
    CHEMISTRY OF MATERIALS, 2003, 15 (08) : 1617 - 1627
  • [28] Photothermal response of superparamagnetic iron oxide nanoparticles
    Kim, Jihoon
    Oh, Junghwan
    Kang, Hyun Wook
    Feldman, Marc D.
    Milner, Thomas E.
    LASERS IN SURGERY AND MEDICINE, 2008, 40 (06) : 415 - 421
  • [29] Superparamagnetic iron oxide nanoparticles with photoswitchable fluorescence
    Yeo, Kyung Min
    Gao, Chun Ji
    Ahn, Kwang-Hyun
    Lee, In Su
    CHEMICAL COMMUNICATIONS, 2008, (38) : 4622 - 4624
  • [30] Multifunctional Nanomedicine Platform for Cancer Specific Delivery of siRNA by Superparamagnetic Iron Oxide Nanoparticles-Dendrimer Complexes
    Taratula, Oleh
    Garbuzenko, Olga
    Savla, Ronak
    Wang, Y. Andrew
    He, Huixin
    Minko, Tamara
    CURRENT DRUG DELIVERY, 2011, 8 (01) : 59 - 69
12345