Increased production of IL-17 in children with autism spectrum disorders and co-morbid asthma

被引：72
|
作者：
Akintunde, Marjannie Eloi [1 ,2 ]
Rose, Melissa [2 ,3 ,4 ]
Krakowiak, Paula [3 ,4 ]
Heuer, Luke [1 ,3 ]
Ashwood, Paul [2 ,3 ,5 ]
Hansen, Robin [2 ,3 ,6 ]
Hertz-Picciotto, Irva [2 ,3 ,4 ]
de Water, Judy Van [1 ,2 ,3 ]
机构：
[1] Univ Calif Davis, Div Rheumatol Allergy & Clin Immunol, Sch Med, Davis, CA 95616 USA
[2] Univ Calif Davis, NIEHS Ctr Childrens Environm Hlth, Davis, CA 95616 USA
[3] Univ Calif Davis, MIND Inst, Davis, CA 95616 USA
[4] Univ Calif Davis, Sch Publ Hlth Sci, Davis, CA 95616 USA
[5] Sch Med, Dept Microbiol & Immunol, Washington, DC USA
[6] Univ Calif Davis, Sch Med, Dept Pediat, Davis, CA 95616 USA
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2015年 / 286卷
关键词：
Autism; IL-17; Asthma; Food allergies; T-CELLS; IMMUNE; INTERLEUKIN-17; LYMPHOCYTES; ENVIRONMENT; EXPRESSION; RESPONSES; RISK;
D O I：
10.1016/j.jneuroim.2015.07.003
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Inflammation and asthma have both been reported in some children with autism spectrum disorder (ASD). To further assess this connection, peripheral immune cells isolated from young children with ASD and typically developing (TD) controls and the production of cytokines IL-17, -13, and -4 assessed following ex vivo mitogen stimulation. Notably, IL-17 production was significantly higher following stimulation in ASD children compared to controls. Moreover, IL-17 was increased in ASD children with co-morbid asthma compared to controls with the same condition. In conclusion, children with ASD exhibited a differential response to T cell stimulation with elevated IL-17 production compared to controls. (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码：33 / 41
页数：9
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