RGD-based PET tracers for imaging receptor integrin αvβ3 expression

被引：66

作者：

Cai, Hancheng ^{[1
,2
]}

Conti, Peter S. ^{[3
]}

机构：

[1] Childrens Hosp Michigan, Detroit Med Ctr, PET Ctr, Detroit, MI 48201 USA

[2] Wayne State Univ, Sch Med, Detroit, MI 48201 USA

[3] Univ So Calif, Keck Sch Med, Dept Radiol, Mol Imaging Ctr, Los Angeles, CA 90033 USA

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2013年 / 56卷 / 05期

关键词：

PET imaging; radiochemistry; integrin; RGD; POSITRON-EMISSION-TOMOGRAPHY; GLY-ASP PEPTIDE; CLICK CHEMISTRY; BREAST-CANCER; COPPER-64; RADIOPHARMACEUTICALS; ALPHA-V-BETA-3; INTEGRIN; BIFUNCTIONAL CHELATOR; BIOLOGICAL EVALUATION; RADIATION-DOSIMETRY; TARGETED DELIVERY;

D O I：

10.1002/jlcr.2999

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Positron emission tomography (PET) imaging of receptor integrin alpha(v)beta(3) expression may play a key role in the early detection of cancer and cardiovascular diseases, monitoring disease progression, evaluating therapeutic response, and aiding anti-angiogenic drugs discovery and development. The last decade has seen the development of new PET tracers for in vivo imaging of integrin alpha(v)beta(3) expression along with advances in PET chemistry. In this review, we will focus on the radiochemistry development of PET tracers based on arginineglycineaspartic acid (RGD) peptide, present an overview of general strategies for preparing RGD-based PET tracers, and review the recent advances in preparations of F-18-labeled, Cu-64-labeled, and Ga-68-labeled RGD tracers, RGD-based PET multivalent probes, and RGD-based PET multimodality probes for imaging receptor integrin alpha(v)beta(3) expression.

引用

页码：264 / 279

页数：16

共 50 条

[21] A pilot study imaging integrin αvβ3 with RGD PET/CT in suspected lung cancer patients
Gao, Song
Wu, Honghu
Li, Wenwu
Zhao, Shuqiang
Teng, Xuepeng
Lu, Hong
Hu, Xudong
Wang, Suzhen
Yu, Jinming
Yuan, Shuanghu
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2015, 42 (13) : 2029 - 2037
[22] In vivo imaging of alpha(v) beta(3) integrin expression with a radiolabeled chimeric RGD peptide
Del Vecchio, S.
Zannetti, A.
Panico, M. R.
Speranza, A.
Iommelli, F.
Papaccioli, A.
Sommella, J.
Lettieri, A.
Saviano, M.
Zaccaro, L.
Del Gatto, A.
Lang, L.
Pedone, C.
Salvatore, M.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2007, 34 : S200 - S200
[23] Integrin (αvβ3) Targeted RGD Peptide Based Probe for Cancer Optical Imaging
Liu, Zhiguo
Yu, Lun
Wang, Xiaobo
Zhang, Xintong
Liu, Meihui
Zeng, Wenbin
CURRENT PROTEIN & PEPTIDE SCIENCE, 2016, 17 (06) : 570 - 581
[24] Imaging of integrin αvβ3 expression
Beer, Ambros J.
Schwaiger, Markus
CANCER AND METASTASIS REVIEWS, 2008, 27 (04) : 631 - 644
[25] Imaging of integrin αvβ3 expression
Ambros J. Beer
Markus Schwaiger
Cancer and Metastasis Reviews, 2008, 27 : 631 - 644
[26] PET/CT Imaging of Integrin αvβ3 Expression in Human Carotid Atherosclerosis
Beer, Ambros J.
Pelisek, Jaroslav
Heider, Peter
Saraste, Antti
Reeps, Christian
Metz, Stephan
Seidl, Stefan
Kessler, Horst
Wester, Hans-Juergen
Eckstein, Hans Henning
Schwaiger, Markus
JACC-CARDIOVASCULAR IMAGING, 2014, 7 (02) : 178 - 187
[27] PET Radiopharmaceuticals for Imaging Integrin Expression: Tracers in Clinical Studies and Recent Developments
Haubner, Roland
Maschauer, Simone
Prante, Olaf
BIOMED RESEARCH INTERNATIONAL, 2014, 2014
[28] A new cyclic RGD peptide dimer for integrin αvβ3 imaging
Ma, H.
Hao, P.
Zhang, L.
Ma, C.
Yan, P.
Wang, R. -F.
Zhang, C. -L.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 2016, 20 (04) : 613 - 619
[29] Insights on RGD-Based Peptide Interactions with Integrin Receptors from Atomistic Simulations
Rammohan, Aravind
Miner, Jacob
Mckenzie, Matthew
BIOPHYSICAL JOURNAL, 2015, 108 (02) : 143A - 143A
[30] PET Diagnostic Molecules Utilizing Multimeric Cyclic RGD Peptide Analogs for Imaging Integrin αvβ3 Receptors
Liolios, Christos
Sachpekidis, Christos
Kolocouris, Antonios
Dimitrakopoulou-Strauss, Antonia
Bouziotis, Penelope
MOLECULES, 2021, 26 (06):

← 1 2 3 4 5 →