RGD-based PET tracers for imaging receptor integrin αvβ3 expression

被引：66

作者：

Cai, Hancheng ^{[1
,2
]}

Conti, Peter S. ^{[3
]}

机构：

[1] Childrens Hosp Michigan, Detroit Med Ctr, PET Ctr, Detroit, MI 48201 USA

[2] Wayne State Univ, Sch Med, Detroit, MI 48201 USA

[3] Univ So Calif, Keck Sch Med, Dept Radiol, Mol Imaging Ctr, Los Angeles, CA 90033 USA

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2013年 / 56卷 / 05期

关键词：

PET imaging; radiochemistry; integrin; RGD; POSITRON-EMISSION-TOMOGRAPHY; GLY-ASP PEPTIDE; CLICK CHEMISTRY; BREAST-CANCER; COPPER-64; RADIOPHARMACEUTICALS; ALPHA-V-BETA-3; INTEGRIN; BIFUNCTIONAL CHELATOR; BIOLOGICAL EVALUATION; RADIATION-DOSIMETRY; TARGETED DELIVERY;

D O I：

10.1002/jlcr.2999

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Positron emission tomography (PET) imaging of receptor integrin alpha(v)beta(3) expression may play a key role in the early detection of cancer and cardiovascular diseases, monitoring disease progression, evaluating therapeutic response, and aiding anti-angiogenic drugs discovery and development. The last decade has seen the development of new PET tracers for in vivo imaging of integrin alpha(v)beta(3) expression along with advances in PET chemistry. In this review, we will focus on the radiochemistry development of PET tracers based on arginineglycineaspartic acid (RGD) peptide, present an overview of general strategies for preparing RGD-based PET tracers, and review the recent advances in preparations of F-18-labeled, Cu-64-labeled, and Ga-68-labeled RGD tracers, RGD-based PET multivalent probes, and RGD-based PET multimodality probes for imaging receptor integrin alpha(v)beta(3) expression.

引用

页码：264 / 279

页数：16

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