Synthesis and evaluation of novel pseudomycin side-chain analogues. Part 3

被引：3
|
作者：
Sun, XC [1 ]
Zhang, YZ [1 ]
Zeckner, D [1 ]
Current, W [1 ]
Chen, SH [1 ]
机构：
[1] Lilly Corp Ctr, A Div Eli Lilly & Co, Lilly Res Labs, Indianapolis, IN 46285 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 23期
关键词：
D O I：
10.1016/S0960-894X(01)00627-8
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
To increase the therapeutic utility of C-18 side-chain bearing pseudomycin analogue 2, we prepared additional analogues and prodrugs of 2 containing further modifications at various positions within its core structure. Each of the newly synthesized derivatives (10-15) exhibited reduced tail vein toxicity relative to the parent compound. Some of the new pseudomycin derivatives (e.g., 14) also showed improved in vivo antifungal activity relative to its corresponding parent compound. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：3055 / 3059
页数：5
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