Localization of the neurokinin 1 receptor on a subset of substance P-positive and isolectin B4-negative dorsal root ganglion neurons of the rat

被引：17

作者：

von Banchet, GS ^{[1
]}

Schaible, HG ^{[1
]}

机构：

[1] Univ Jena, Inst Physiol, D-07740 Jena, Germany

来源：

NEUROSCIENCE LETTERS | 1999年 / 274卷 / 03期

关键词：

NK1; receptor; substance P; isolectin B4; colocalisation; dorsal root ganglion; rat;

D O I：

10.1016/S0304-3940(99)00719-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Dorsal root ganglion (DRG) neurons that express the neurokinin 1 (NK1) receptor were further characterized immunocytochemically using double-labeling techniques. DRG neurons were isolated from adult rats and cultured for 1-4 days. NK1 receptors on the surface of the neurons were labeled with substance P-gold. Non-peptidergic neurons were labeled with the surface marker isolectin B4 from Griffonia simplicifolia (IB4). Substance P-immunoreactivity was determined using an antibody to substance P. NK1 receptors were not identified on non-peptidergic neurons. The vast majority of the neurons with NK1 receptors showed substance P-immunoreactivity suggesting that NK1 receptors are autoreceptors in many dorsal root ganglion neurons. (C) 1999 Published by Elsevier Science Ireland Ltd. Ail rights reserved.

引用

页码：175 / 178

页数：4

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