C-Reactive Protein and Cognition Are Unrelated to Leukoaraiosis

被引：4

作者：

Rizzi, Liara ^{[1
]}

Marques, Fabricio Correia ^{[1
]}

Rosset, Idiane ^{[2
]}

Moriguchi, Emilio Hideyuki ^{[3
]}

Picon, Paulo Dornelles ^{[3
]}

Fagundes Chaves, Marcia Lorena ^{[1
,3
]}

Roriz-Cruz, Andmatheus ^{[1
,3
]}

机构：

[1] HCPA, Div Geriatr Neurol, Serv Neurol, BR-90035903 Porto Alegre, RS, Brazil

[2] Univ Fed Rio Grande do Sul, Fac Nursing, Div Gerontol Nursing, BR-90620110 Porto Alegre, RS, Brazil

[3] Univ Fed Rio Grande do Sul, Fac Med, Dept Internal Med, BR-90035903 Porto Alegre, RS, Brazil

来源：

SCIENTIFIC WORLD JOURNAL | 2014年

关键词：

SMALL-VESSEL DISEASE; WHITE-MATTER HYPERINTENSITIES; OLDER-ADULTS; INFLAMMATORY PROTEINS; DEMENTIA; MARKERS; STROKE; INTERLEUKIN-6; ASSOCIATION; DYSFUNCTION;

D O I：

10.1155/2014/121679

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Elevated serum levels of C-reactive protein (CRP) have been associated with leukoaraiosis in elderly brain. However, several studies indicate that leukoaraiosis is associated with an increased risk of cognitive impairment. It is unknown how the effect of CRP on cognition is mediated by leukoaraiosis. The purpose of this study is to assess the relationship between serum levels of CRP, the presence of leukoaraiosis, and cognitive impairment in a population of coronary patients over 50 years old. CRP levels explained 7.18% (P: 0.002) of the variance of the MMSE. The adjustment for the presence of leukoaraiosis little changed this variance (5.98%,P: 0.005), indicating that only a small portion of the CRP influence on cognition was mediated via leukoaraiosis. Patients with CRP levels >= 5.0 had 2.9 (95% CI: 1.26-6.44) times more chance to present cognitive impairment (P: 0.012). We found that elevated serum levels of CRP were associated with increased risk of cognitive impairment in elderly and it was not mediated by presence of leukoaraiosis.

引用

页数：8

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