No association between neuropathy and restless legs in Parkinson's disease

被引:14
|
作者
Rajabally, Y. A. [1 ]
Martey, J. [1 ]
机构
[1] Univ Hosp Leicester, Dept Neurol, Leicester, Leics, England
来源
ACTA NEUROLOGICA SCANDINAVICA | 2013年 / 127卷 / 03期
关键词
levodopa; leg motor restlessness; neuropathy; Parkinson's disease; restless legs syndrome; vitamin B12; MOTOR RESTLESSNESS; PREVALENCE; SCALE; RISK; RLS;
D O I
10.1111/ane.12011
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background The prevalence of restless legs syndrome (RLS) has been studied extensively in Parkinson's disease (PD), with conflicting findings. More recently, both neuropathy and leg motor restlessness (LMR) have been found to be significantly more prevalent in PD patients than in controls. Aims Our objective was to determine whether RLS or LMR may be secondary to neuropathy, or its currently postulated determinants, cumulative levodopa usage and vitamin B12 metabolism, in patients with PD. Materials and Methods We compared prevalence of RLS, LMR and neuropathy in 37 PD patients and 37 age- and gender-matched controls. Correlations between RLS/LMR and neuropathy and symptomatic neuropathy, cumulative levodopa usage and vitamin B12 levels were ascertained. Results RLS prevalence was comparable in PD patients and controls (16.2% vs 10.8%; P=0.30). LMR was significantly more common in PD patients than in controls (40.5% vs 16.2%; P=0.038), as was neuropathy (37.8% vs 8.1%; P=0.005). Neither RLS, nor LMR correlated with neuropathy or symptomatic neuropathy, cumulative levodopa exposure or serum vitamin B12 levels in patients with PD. There was a non-significant trend for a correlation between LMR and earlier age of onset of PD (P=0.069). Conclusions RLS and LMR appear unrelated to neuropathy or symptomatic neuropathy, cumulative levodopa usage, or serum vitamin B12 levels in patients with PD. The occurrence of LMR may relate to the earlier onset of PD, raising the possibility of common pathophysiological mechanisms for PD and RLS, of which LMR may be an early manifestation in some patients.
引用
收藏
页码:216 / 220
页数:5
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