1-(7-Chloroquinolin-4-yl)-2-[(1H-pyrrol-2-yl)methylene]hydrazine: a potent compound against cancer

被引：13
|
作者：
Montenegro, Raquel Carvalho [4 ]
Lotufo, Leticia Veras [3 ]
de Moraes, Manoel Odorico [3 ]
Pessoa, Claudia do O. [3 ]
Rocha Rodrigues, Felipe Augusto [3 ]
Ferreira Bispo, Marcelle de Lima [1 ,2 ]
de Alcantara, Camila Cataldi [1 ]
Kaiser, Carlos Roland [2 ]
Nora de Souza, Marcus Vinicius [1 ]
机构：
[1] Fundacao Oswaldo Cruz, Inst Tecnol Farmacos Far Manguinhos, BR-21041250 Rio De Janeiro, RJ, Brazil
[2] Univ Fed Rio de Janeiro, Dept Quim Organ, Inst Quim, BR-21945970 Rio De Janeiro, RJ, Brazil
[3] Univ Fed Ceara, Expt Oncol Lab, Fortaleza, Ceara, Brazil
[4] Fed Univ Para, Lab Genet Humana & Med, BR-66059 Belem, Para, Brazil
来源：
MEDICINAL CHEMISTRY RESEARCH | 2012年 / 21卷 / 11期
关键词：
Antitumor activity; Cancer; Chloroquine; Drugs; Hydrazones; Quinoline; ACID;
D O I：
10.1007/s00044-011-9894-8
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Heteroaromatic derivatives (3a-f) have been synthesized and evaluated for their activity against four cancer cell lines. Among the studied compounds, 1-(7-Chloroquinolin-4-yl)-2-[(1H-pyrrol-2-yl)methylene]hydrazine (3e) exhibited an excellent cytotoxic activity against the referred lines, and especially on melanoma cells (MDAMB-435). In this case, compound 3e is four times more active than the standard substance Doxorubicin. Together with other results from our group, 7-chloro-4-quinolinylhydrazones derived from chloroquine could be considered a relevant finding toward the rational design of new leads for antitumor compounds.
引用
收藏
页码：3615 / 3619
页数：5
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