1-(7-Chloroquinolin-4-yl)-2-[(1H-pyrrol-2-yl)methylene]hydrazine: a potent compound against cancer

被引：13

作者：

Montenegro, Raquel Carvalho ^{[4
]}

Lotufo, Leticia Veras ^{[3
]}

de Moraes, Manoel Odorico ^{[3
]}

Pessoa, Claudia do O. ^{[3
]}

Rocha Rodrigues, Felipe Augusto ^{[3
]}

Ferreira Bispo, Marcelle de Lima ^{[1
,2
]}

de Alcantara, Camila Cataldi ^{[1
]}

Kaiser, Carlos Roland ^{[2
]}

Nora de Souza, Marcus Vinicius ^{[1
]}

机构：

[1] Fundacao Oswaldo Cruz, Inst Tecnol Farmacos Far Manguinhos, BR-21041250 Rio De Janeiro, RJ, Brazil

[2] Univ Fed Rio de Janeiro, Dept Quim Organ, Inst Quim, BR-21945970 Rio De Janeiro, RJ, Brazil

[3] Univ Fed Ceara, Expt Oncol Lab, Fortaleza, Ceara, Brazil

[4] Fed Univ Para, Lab Genet Humana & Med, BR-66059 Belem, Para, Brazil

来源：

MEDICINAL CHEMISTRY RESEARCH | 2012年 / 21卷 / 11期

关键词：

Antitumor activity; Cancer; Chloroquine; Drugs; Hydrazones; Quinoline; ACID;

D O I：

10.1007/s00044-011-9894-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Heteroaromatic derivatives (3a-f) have been synthesized and evaluated for their activity against four cancer cell lines. Among the studied compounds, 1-(7-Chloroquinolin-4-yl)-2-[(1H-pyrrol-2-yl)methylene]hydrazine (3e) exhibited an excellent cytotoxic activity against the referred lines, and especially on melanoma cells (MDAMB-435). In this case, compound 3e is four times more active than the standard substance Doxorubicin. Together with other results from our group, 7-chloro-4-quinolinylhydrazones derived from chloroquine could be considered a relevant finding toward the rational design of new leads for antitumor compounds.

引用

页码：3615 / 3619

页数：5

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