Alzheimer's lymphocytes are resistant to ultraviolet B-induced apoptosis

被引：3

作者：

Zana, M

Juhász, A

Rimanóczy, A

Bjelik, A

Baltás, E

Ocsovszki, I

Boda, K

Penke, B

Dobozy, A

Kemény, L

Janka, Z

Kálmán, J

机构：

[1] Univ Szeged, Dept Psychiat, Albert Szent Gyorgyi Ctr Med & Pharmaceut Sci, H-6725 Szeged, Hungary

[2] Univ Szeged, Dept Dermatol, Albert Szent Gyorgyi Ctr Med & Pharmaceut Sci, H-6720 Szeged, Hungary

[3] Univ Szeged, Dept Biochem, Albert Szent Gyorgyi Ctr Med & Pharmaceut Sci, H-6720 Szeged, Hungary

[4] Univ Szeged, Dept Med Informat, Albert Szent Gyorgyi Ctr Med & Pharmaceut Sci, H-6720 Szeged, Hungary

[5] Univ Szeged, Dept Med Chem, Albert Szent Gyorgyi Ctr Med & Pharmaceut Sci, Fac Med, H-6720 Szeged, Hungary

来源：

NEUROBIOLOGY OF AGING | 2006年 / 27卷 / 06期

基金：

匈牙利科学研究基金会;

关键词：

Alzheimer's disease; apoptosis; T-lymphocytes; ultraviolet B irradiation; flow cytometry;

D O I：

10.1016/j.neurobiolaging.2005.04.007

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

In the present pilot investigation, the susceptibility of T-lymphocytes from Alzheimer's disease (AD) subjects (n = 22) and aged-matched, non-demented controls (CNT) (n = 12) was examined with ultraviolet (UV) B light-induced apoptosis in vitro. The basal apoptotic ratios were similar in both groups. However, the AD lymphocytes displayed significantly (p < 0.0001) lower apoptotic levels than those of the CNT lymphocytes at all of the applied UVB exposure doses (100, 200 and 300 mJ/cm(2)). These observations indicate that AD lymphocytes are more resistant than CNT lymphocytes to UVB irradiation. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：831 / 834

页数：4

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