Alzheimer's lymphocytes are resistant to ultraviolet B-induced apoptosis

被引：3
|
作者：
Zana, M
Juhász, A
Rimanóczy, A
Bjelik, A
Baltás, E
Ocsovszki, I
Boda, K
Penke, B
Dobozy, A
Kemény, L
Janka, Z
Kálmán, J
机构：
[1] Univ Szeged, Dept Psychiat, Albert Szent Gyorgyi Ctr Med & Pharmaceut Sci, H-6725 Szeged, Hungary
[2] Univ Szeged, Dept Dermatol, Albert Szent Gyorgyi Ctr Med & Pharmaceut Sci, H-6720 Szeged, Hungary
[3] Univ Szeged, Dept Biochem, Albert Szent Gyorgyi Ctr Med & Pharmaceut Sci, H-6720 Szeged, Hungary
[4] Univ Szeged, Dept Med Informat, Albert Szent Gyorgyi Ctr Med & Pharmaceut Sci, H-6720 Szeged, Hungary
[5] Univ Szeged, Dept Med Chem, Albert Szent Gyorgyi Ctr Med & Pharmaceut Sci, Fac Med, H-6720 Szeged, Hungary
来源：
NEUROBIOLOGY OF AGING | 2006年 / 27卷 / 06期
基金：
匈牙利科学研究基金会;
关键词：
Alzheimer's disease; apoptosis; T-lymphocytes; ultraviolet B irradiation; flow cytometry;
D O I：
10.1016/j.neurobiolaging.2005.04.007
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
In the present pilot investigation, the susceptibility of T-lymphocytes from Alzheimer's disease (AD) subjects (n = 22) and aged-matched, non-demented controls (CNT) (n = 12) was examined with ultraviolet (UV) B light-induced apoptosis in vitro. The basal apoptotic ratios were similar in both groups. However, the AD lymphocytes displayed significantly (p < 0.0001) lower apoptotic levels than those of the CNT lymphocytes at all of the applied UVB exposure doses (100, 200 and 300 mJ/cm(2)). These observations indicate that AD lymphocytes are more resistant than CNT lymphocytes to UVB irradiation. (c) 2005 Elsevier Inc. All rights reserved.
引用
收藏
页码：831 / 834
页数：4
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