Synthesis of 4,5,6-trisubstituted 2,3-pyridinediones via Mannich reaction and oxidation-Michael addition of 3-hydroxy-2(1H)-pyridinones

被引：0

作者：

Xie, Wen Lin ^{[1
]}

Xiao, Chuang Ping ^{[1
]}

Xie, Ling ^{[1
]}

Zhou, Ying ^{[1
]}

Li, Xue Feng ^{[1
]}

Tang, Xu Fu ^{[1
]}

Yuan, Chun Tao ^{[1
]}

Qiu, Ming Hua ^{[1
]}

机构：

[1] Hunan Univ Sci & Technol, Key Lab Theoret Chem & Mol Simulat, Sch Chem & Chem Engn, Hunan Prov Univ Key Lab QSAR QSPR,Minist Educ, Xiangtan 411201, Peoples R China

来源：

RESEARCH ON CHEMICAL INTERMEDIATES | 2012年 / 38卷 / 07期

关键词：

Pyridinone; Mannich reaction; Oxidation; Michael addition; IRON;

D O I：

10.1007/s11164-012-0495-z

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

4-Substituted 3-hydroxy-2(1H)-pyridinones 2 were prepared by Mannich reaction of 3-hydroxy-2(1H)-pyridinones with secondary amines and formaldehyde. The isolated products were then reacted with aromatic amines in the presence of NaIO3 as oxidant via oxidation-Michael addition to yield 4,5,6-trisubstituted-2,3-pyridinediones 3 in good yields (80.2-88.9%). The structures of the products were characterized by H-1 NMR, ESI-MS, and IR, and elemental analysis.

引用

页码：1699 / 1705

页数：7

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