U1 snRNA Rewrites the "Script"

被引：6
|
作者：
Merkhofer, Evan C. [1 ]
Johnson, Tracy L. [1 ]
机构：
[1] Univ Calif San Diego, Mol Biol Sect, Div Biol Sci, La Jolla, CA 92093 USA
来源：
CELL | 2012年 / 150卷 / 01期
基金：
美国国家科学基金会;
关键词：
MESSENGER-RNA POLYADENYLATION; POLY(A) POLYMERASE;
D O I：
10.1016/j.cell.2012.06.017
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Expression of eukaryotic mRNAs requires the collaboration of a host of RNA processing factors acting upon the transcript. Berg et al. describe how a pre-mRNA splicing factor modulates the activity of the polyadenylation machinery to regulate mRNA length, with important implications for isoform expression in activated neuronal and immune cells.
引用
收藏
页码：9 / 11
页数：4
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