U1 snRNA Rewrites the "Script"

被引：6
|
作者：
Merkhofer, Evan C. [1 ]
Johnson, Tracy L. [1 ]
机构：
[1] Univ Calif San Diego, Mol Biol Sect, Div Biol Sci, La Jolla, CA 92093 USA
来源：
CELL | 2012年 / 150卷 / 01期
基金：
美国国家科学基金会;
关键词：
MESSENGER-RNA POLYADENYLATION; POLY(A) POLYMERASE;
D O I：
10.1016/j.cell.2012.06.017
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Expression of eukaryotic mRNAs requires the collaboration of a host of RNA processing factors acting upon the transcript. Berg et al. describe how a pre-mRNA splicing factor modulates the activity of the polyadenylation machinery to regulate mRNA length, with important implications for isoform expression in activated neuronal and immune cells.
引用
收藏
页码：9 / 11
页数：4
相关论文
共 50 条
  • [1] CONTRIBUTION OF U1 SNRNA STRUCTURAL DOMAINS TO U1 SNRNP FUNCTION
    LIAO, XL
    KRETZNER, L
    SERAPHIN, B
    ROSBASH, M
    MOLECULAR BIOLOGY REPORTS, 1990, 14 (2-3) : 143 - 143
  • [2] PRIMARY STRUCTURE OF THE CANINE U1 SNRNA
    VERMA, M
    OLNES, MJ
    KURL, RN
    DAVIDSON, EA
    GENE, 1995, 154 (02) : 255 - 257
  • [3] FORMATION OF THE 3' END OF U1 SNRNA
    DAHLBERG, JE
    YANG, H
    DEVEGVAR, HN
    LUND, E
    MOLECULAR BIOLOGY REPORTS, 1990, 14 (2-3) : 161 - 162
  • [4] INVITRO SYNTHESIS OF VERTEBRATE U1 SNRNA
    LUND, E
    DAHLBERG, JE
    EMBO JOURNAL, 1989, 8 (01): : 287 - 292
  • [5] Chemical Synthesis of U1 snRNA Derivatives
    Ohkubo, Akihiro
    Kondo, Yasushi
    Suzuki, Makoto
    Kobayashi, Haruki
    Kanamori, Takashi
    Masaki, Yoshiaki
    Seio, Kohji
    Nagai, Kiyoshi
    Sekine, Mitsuo
    ORGANIC LETTERS, 2013, 15 (17) : 4386 - 4389
  • [6] The increasing functional repertoire of U1 snRNA
    West, Steven
    BIOCHEMICAL SOCIETY TRANSACTIONS, 2012, 40 : 846 - 849
  • [7] Assembly of the U1 snRNP involves interactions with the backbone of the terminal stem of U1 snRNA
    McConnell, TS
    Lokken, RP
    Steitz, JA
    RNA, 2003, 9 (02) : 193 - 201
  • [8] Reduction of gene expression by a modified U1 snRNA
    Beckley, SA
    Stover, ML
    Lichtler, AC
    Rowe, DW
    MATRIX BIOLOGY, 1998, 17 (02) : 163 - 164
  • [9] DROSOPHILA-MELANOGASTER U1 SNRNA GENES
    ALONSO, A
    JORCANO, JL
    BECK, E
    HOVEMANN, B
    SCHMIDT, T
    JOURNAL OF MOLECULAR BIOLOGY, 1984, 180 (04) : 825 - 836
  • [10] CHARACTERIZATION OF THE 70-KD U1 SNRNP PROTEIN AND ITS INTERACTION WITH U1 SNRNA
    SPRITZ, RA
    STRUNK, K
    SUROWY, CS
    HOCH, S
    MOLECULAR BIOLOGY REPORTS, 1987, 12 (03) : 161 - 161
12345