Application of capillary zone electrophoresis for analyzing biotin in pharmaceutical formulations - A comparative study

被引：23
|
作者：
Schiewe, J [1 ]
Gobel, S [1 ]
Schwarz, M [1 ]
Neubert, R [1 ]
机构：
[1] UNIV HALLE WITTENBERG, INST PHARMACEUT & BIOPHARMACEUT, D-06120 HALLE, GERMANY
来源：
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1996年 / 14卷 / 04期
关键词：
biotin analysis; capillary zone electrophoresis; spectrophotometry; determination of sulphur content; drug analysis; pharmaceutical formulations;
D O I：
10.1016/0731-7085(95)01641-4
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The detection limit and reproducibility of capillary zone electrophoresis (CZE) measurement of biotin were compared to those of a spectrophotometric method and those of the determination of the sulphur content by combustion of the biotin sample followed by coulometric titration of the formed SO2. Drug analysis showed that all three methods gave consistent results and were suitable for the determination of biotin. CZE was found to be the best method for the determination of pharmaceutical formulations containing biotin because of its high separation efficiency, short analysis time, ease of instrumentation and sample preconditioning, and good precision.
引用
收藏
页码：435 / 439
页数：5
相关论文
共 50 条
  • [31] Analysis of protamine peptides in insulin pharmaceutical formulations by capillary electrophoresis
    Lamalle, Caroline
    Servais, Anne-Catherine
    Demelenne, Alice
    Crommen, Jacques
    Fillet, Marianne
    JOURNAL OF SEPARATION SCIENCE, 2016, 39 (06) : 1189 - 1194
  • [32] Simultaneous Determination of Bromhexine and Amoxicillin in Pharmaceutical Formulations by Capillary Electrophoresis
    Cruz Oliva, Denise
    Torres Velez, Karina
    Revilla Vazquez, Alma Luisa
    JOURNAL OF THE MEXICAN CHEMICAL SOCIETY, 2011, 55 (02) : 79 - 83
  • [33] Capillary zone electrophoresis for determination of vildagliptin (a DPP-4 inhibitor) in pharmaceutical formulation and comparative study with HPLC
    Barden, A. T.
    Piccoli, B. L.
    Volpato, N. M.
    Schapoval, E. E. S.
    Steppe, M.
    PHARMAZIE, 2014, 69 (02): : 86 - 91
  • [34] CAPILLARY ZONE ELECTROPHORESIS - SOME PROMISING PHARMACEUTICAL APPLICATIONS
    FAZIO, S
    VIVILECCHIA, R
    LESUEUR, L
    SHERIDAN, J
    AMERICAN BIOTECHNOLOGY LABORATORY, 1990, 8 (01): : 10 - &
  • [35] Determination of sertaconazole in pharmaceutical preparations by capillary zone electrophoresis
    Nemutlu, E
    Yardimci, C
    Özaltin, N
    ANALYTICA CHIMICA ACTA, 2005, 547 (01) : 83 - 88
  • [36] DETERMINATION OF CIMETIDINE IN PHARMACEUTICAL PREPARATIONS BY CAPILLARY ZONE ELECTROPHORESIS
    ARROWOOD, S
    HOYT, AM
    JOURNAL OF CHROMATOGRAPHY, 1991, 586 (01): : 177 - 180
  • [37] PHARMACEUTICAL ANALYSIS BY CAPILLARY ZONE ELECTROPHORESIS AND MICELLAR ELECTROKINETIC CAPILLARY CHROMATOGRAPHY
    ALTRIA, KD
    SMITH, NW
    JOURNAL OF CHROMATOGRAPHY, 1991, 538 (02): : 506 - 509
  • [38] Optimization, Validation and Application of a Capillary Zone Electrophoresis Method for the Assay of Sparfloxacin in Pharmaceutical Formulation
    Elbashir, Abdalla A.
    Saad, Bahruddin
    Ali, Abdussalam Salhin Mohamed
    Saleh, Muhd. Idiris
    Aboul-Enein, Hassan Y.
    ANALYTICAL LETTERS, 2008, 41 (14) : 2608 - 2620
  • [39] Study of on-line stacking procedures for analyzing marbofloxacin by capillary zone electrophoresis
    Hernández, M
    Borrull, F
    Calull, M
    CHROMATOGRAPHIA, 2002, 55 (9-10) : 585 - 590
  • [40] Study of on-line stacking procedures for analyzing marbofloxacin by capillary zone electrophoresis
    M. Hernández
    F. Borrull
    M. Calull
    Chromatographia, 2002, 55 : 585 - 590
12345