Association of TCF7L2 Polymorphism with Diabetic Nephropathy in the South Indian Population

被引：10
|
作者：
Bodhini, Dhanasekaran [1 ]
Chidambaram, Manickam [1 ,2 ]
Liju, Samuel [1 ]
Prakash, Visvanathan G. [1 ]
Gayathri, Vijay [1 ]
Shanthirani, Coimbatore S. [1 ]
Ranjith, Unnikrishnan [3 ]
Anjana, Ranjit M. [1 ,3 ]
Mohan, Viswanathan [1 ,3 ]
Radha, Venkatesan [1 ]
机构：
[1] Madras Diabet Res Fdn, Madras 600086, Tamil Nadu, India
[2] Qatar Cardiovasc Res Ctr, Doha, Qatar
[3] IDF Ctr Educ, Dr Mohans Diabet Special Ctr, WHO Collaborating Ctr Noncommunicable Dis Prevent, Madras, Tamil Nadu, India
来源：
ANNALS OF HUMAN GENETICS | 2015年 / 79卷 / 05期
关键词：
TCF7L2; gene; rs12255372; variant; diabetic nephropathy; type; 2; diabetes; south Indians; URBAN-RURAL EPIDEMIOLOGY; STAGE RENAL-DISEASE; GENE POLYMORPHISM; TYPE-2; VARIANTS; RISK; PROGRESSION; MELLITUS; RETINOPATHY; PREVALENCE;
D O I：
10.1111/ahg.12122
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The transcription factor 7-like 2 (TCF7L2) gene plays a significant role in the development of type 2 diabetes and diabetic nephropathy. The aim of this study was to investigate the association of TCF7L2 rs12255372 (G/T)polymorphism with type 2 diabetic nephropathy in the South Indian population. A total of 2102 subjects, 927 normal glucose tolerant (NGT) subjects, 598 type 2 diabetic subjects without nephropathy (DM), and 577 type 2 diabetic subjects with nephropathy (DN) were genotyped by MassARRAY. As compared to the NGT group, the odds ratio (adjusted for age, sex, BMI, HbA1c, and systolic BP) computed for the GT/TT genotype taking the GG genotype as reference was found to be 2.02 (95% CI: 1.16-3.51, p = 0.013) for DN and 1.94 (95% CI: 1.36-2.78, p = 0.0002) for DM. The genotype frequency was not significantly different between the DM and DN groups. In conclusion, the rs12255372 polymorphism in the TCF7L2 gene is associated with type 2 diabetes and DN but its association with DN is mediated through diabetes.
引用
收藏
页码：373 / 379
页数：7
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