Concurrent inhibition of c-Met and VEGF signaling suppresses tumor invasion in orthotopic Panc-1 pancreatic carcinomas in mice

被引:0
|
作者
Sennino, Barbara [1 ]
Williamson, Casey W. [1 ]
Bhagwandin, Vikash [1 ]
Christensen, James G. [2 ]
McDonald, Donald M. [1 ]
机构
[1] UCSF, San Francisco, CA USA
[2] Pfizer Global Res & Dev, La Jolla, CA USA
关键词
D O I
10.1158/1538-7445.AM2012-1378
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
1378
引用
收藏
页数:2
相关论文
共 50 条
  • [21] HGF/c-met/Stat3 signaling during skin tumor cell invasion: indications for a positive feedback loop
    Zanobia A Syed
    Weihong Yin
    Kendall Hughes
    Jennifer N Gill
    Runhua Shi
    John L Clifford
    BMC Cancer, 11
  • [22] Rasfonin, a novel 2-pyrone derivative, induces ras-mutated Panc-1 pancreatic tumor cell death in nude mice
    Xiao, Z.
    Li, L.
    Li, Y.
    Zhou, W.
    Cheng, J.
    Liu, F.
    Zheng, P.
    Zhang, Y.
    Che, Y.
    CELL DEATH & DISEASE, 2014, 5 : e1241 - e1241
  • [23] Rasfonin, a novel 2-pyrone derivative, induces ras-mutated Panc-1 pancreatic tumor cell death in nude mice
    Z Xiao
    L Li
    Y Li
    W Zhou
    J Cheng
    F Liu
    P Zheng
    Y Zhang
    Y Che
    Cell Death & Disease, 2014, 5 : e1241 - e1241
  • [24] TGFβ Signaling Increases Net Acid Extrusion, Proliferation and Invasion in Panc-1 Pancreatic Cancer Cells: SMAD4 Dependence and Link to Merlin/NF2 Signaling
    Malinda, Raj R.
    Zeeberg, Katrine
    Sharku, Patricia C.
    Ludwig, Mette Q.
    Pedersen, Lotte B.
    Christensen, Soren T.
    Pedersen, Stine F.
    FRONTIERS IN ONCOLOGY, 2020, 10
  • [25] Hepatocyte Growth Factor/c-Met Pathway Inhibition Combined Chemotherapy Improves Tumor Immunity and Eliminates Metastasis in Pancreatic Cancer
    Mekapogu, A. R.
    Xu, Z.
    Pothula, S. P.
    Perera, C.
    Pang, T.
    Hosen, S.
    Damalanka, V.
    Mahoney, M.
    Janetka, J.
    Klampfer, L.
    Goldstein, D.
    Pirola, R. C.
    Wilson, J. S.
    Apte, M. V.
    PANCREAS, 2021, 50 (07) : 1082 - 1082
  • [26] BPI-9016M, a c-Met inhibitor, suppresses tumor cell growth, migration and invasion of lung adenocarcinoma via miR203-DKK1
    Zhang, Panpan
    Li, Shaolei
    Lv, Chao
    Si, Jiahui
    Xiong, Ying
    Ding, Lieming
    Ma, Yuanyuan
    Yang, Yue
    THERANOSTICS, 2018, 8 (21): : 5890 - 5902
  • [27] Crizotinib inhibits tumor growth and metabolic inactivation of gemcitabine in new patient derived orthotopic pancreatic tumors with c-Met overexpression: A step toward personalized treatment in pancreatic cancer
    Avan, Amir
    Caretti, Viola
    Funel, Niccola
    Galvani, Elena
    Maftouh, Mina
    Honeywell, Richard J.
    Lagerweij, Tonny
    Campani, Daniela
    Verheul, Henk M.
    Schuurhuis, Gerrit Jan
    Boggi, Ugo
    Peters, Godefridus J.
    Wurdinger, Thomas
    Giovannetti, Elisa
    CANCER RESEARCH, 2014, 74 (19)
  • [28] Garcinol downregulates Notch1 signaling via modulating miR-200c and suppresses oncogenic properties of PANC-1 cancer stem-like cells
    Huang, Chi-Cheng
    Lin, Chien-Min
    Huang, Yan-Jiun
    Wei, Li
    Ting, Lei-Li
    Kuo, Chia-Chun
    Hsu, Cheyu
    Chiou, Jeng-Fong
    Wu, Alexander T. H.
    Lee, Wei-Hwa
    BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY, 2017, 64 (02) : 165 - 173
  • [29] Tolfenamic acid decreases c-Met expression through Sp proteins degradation and inhibits lung cancer cells growth and tumor formation in orthotopic mice
    Colon, Jimmie
    Basha, Md. Riyaz
    Madero-Visbal, Rafael
    Konduri, Santhi
    Baker, Cheryl H.
    Herrera, Luis J.
    Safe, Stephen
    Sheikh-Hamad, David
    Abudayyeh, Ala
    Alvarado, Beatrice
    Abdelrahim, Maen
    INVESTIGATIONAL NEW DRUGS, 2011, 29 (01) : 41 - 51
  • [30] Tolfenamic acid decreases c-Met expression through Sp proteins degradation and inhibits lung cancer cells growth and tumor formation in orthotopic mice
    Jimmie Colon
    Md. Riyaz Basha
    Rafael Madero-Visbal
    Santhi Konduri
    Cheryl H. Baker
    Luis J. Herrera
    Stephen Safe
    David Sheikh-Hamad
    Ala Abudayyeh
    Beatrice Alvarado
    Maen Abdelrahim
    Investigational New Drugs, 2011, 29 : 41 - 51