Failure to detect Chlamydia pneumoniae in coronary atheromas of patients undergoing atherectomy

被引:164
|
作者
Weiss, SM
Roblin, PM
Gaydos, CA
Cummings, P
Patton, DL
Schulhoff, N
Shani, J
Frankel, R
Penney, K
Quinn, TC
Hammerschlag, MR
Schachter, J
机构
[1] SUNY HLTH SCI CTR,DEPT MED,DIV INFECT DIS,BROOKLYN,NY 11203
[2] SUNY HLTH SCI CTR,DEPT PEDIAT,DIV INFECT DIS,BROOKLYN,NY 11203
[3] MAIMONIDES HOSP,DIV CARDIOL,BROOKLYN,NY 11219
[4] JOHNS HOPKINS UNIV,SCH MED,DEPT MED,DIV INFECT DIS,BALTIMORE,MD
[5] NIAID,IMMUNOREGULAT LAB,BETHESDA,MD 20892
[6] WASHINGTON UNIV,DEPT OBSTET & GYNECOL,SEATTLE,WA
[7] UNIV CALIF SAN FRANCISCO,DEPT LAB MED,SAN FRANCISCO,CA 94143
来源
JOURNAL OF INFECTIOUS DISEASES | 1996年 / 173卷 / 04期
关键词
D O I
10.1093/infdis/173.4.957
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
To further investigate a proposed relationship between Chlamydia pneumoniae and coronary heart disease, coronary atheromas were collected from patients undergoing percutaneous atherectomy, Fifty-eight atheroma specimens were examined by culture and polymerase chain reaction (PCR) and 22 by electron microscopy, All were negative for C. pneumoniae, except a single specimen that was PCR-positive, These results differ from studies in other populations, in which this organism was identified by nonculture methods within coronary atheromas obtained at autopsy, Anti-C, pneumoniae antibody titers from 65 of the patients were compared with those of 28 asymptomatic controls, IgG titers were higher in controls than in patients, There is no evidence that C. pneumoniae exists within atheromas in this study population, nor does seroprevalence correlate with the presence of coronary disease in these patients.
引用
收藏
页码:957 / 962
页数:6
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