SYNTHESIS AND BIOLOGICAL EVALUATION OF NEW BENZOFURANYL ISOXAZOLES AS ANTITUBERCULAR, ANTIBACTERIAL AND ANTIFUNGAL AGENTS

被引：0
|
作者：
Manna, K. [1 ]
Agarwal, Y. K. [1 ]
Srinivasan, K. K. [2 ]
机构：
[1] Nirma Univ Sci & Technol, Inst Pharm, Ahmadabad, Gujarat, India
[2] Manipal Acad Higher Educ, Manipal Coll Pharmaceut Sci, Manipal 576119, India
来源：
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 2008年 / 18卷 / 01期
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中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Substituted benzofuran chalcones (2a-n) were prepared by the reaction of 2-acetyl benzofuran (1) with different aromatic aldehydes in presence of strong base. Benzofuran chalcones (2a-n) on cyclocondensation with hydroxylamine hydrochloride in presence of sodium acetate, gave various 3-(1-benzofuran-2-yl)-5-phenylisoxazoles (3a-n). The structure of benzofuran isoxazoles 3a-n have been established on the basis of spectral (IR, (1)H NMR, Mass) data. The benzofuran isoxazoles were evaluated for their, antitubercular, antimicrobial and antiinflammatory activities. Some of the compounds have shown promising antitubercular and antibacterial activity.
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页码：87 / 88
页数：2
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