Transient decrease of HPC-1/syntaxin-1A mRNA in the rat hippocampus by kainic acid

被引：5
|
作者：
Fujino, I
Fujiwara, T
Akagawa, K
机构：
[1] Department of Physiology, Kyorin University School of Medicine, Mitaka, Tokyo 181, 6-20-1, Shinkawa
来源：
NEUROSCIENCE RESEARCH | 1997年 / 28卷 / 03期
关键词：
HPC-1/syntaxin-1A; kainic acid; rat hippocampus; in situ hybridization; RT-PCR;
D O I：
10.1016/S0168-0102(97)00050-3
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
HPC-1/syntaxin-1A is a neuronal protein of which the mRNA has an immediate early gene-like structure in its 3'-untranslated region. Whereas HPC-1/syntaxin-1A protein plays a crucial role in neurotransmitter release, little is known about HPC-1 gene expression. We demonstrate here that HPC-1 mRNA expression in rat hippocampal neurons in vivo decreased 8 h after kainic acid (KA) administration, but was restored thereafter. The transient decrease of HPC-1 mRNA upon KA administration suggests that the HPC-1 mRNA expression in neurons could be altered by excitation by trans-synaptic stimulation. (C) 1997 Elsevier Science Ireland Ltd.
引用
收藏
页码：243 / 247
页数：5
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