The MAPT locus-a genetic paradigm in disease susceptibility

被引：23
|
作者：
Wade-Martins, Richard [1 ]
机构：
[1] Univ Oxford, Oxford Parkinsons Dis Ctr, Dept Physiol Anat & Genet, Oxford OX1 3QX, England
来源：
NATURE REVIEWS NEUROLOGY | 2012年 / 8卷 / 09期
基金：
英国惠康基金;
关键词：
HAPLOTYPE-SPECIFIC EXPRESSION; DIFFERENTIAL REGULATION; TAU; RISK;
D O I：
10.1038/nrneurol.2012.169
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Understanding how genetic variation can confer susceptibility to neurological disease is an urgent priority. A new gene-expression study has explored the relationship between DNA sequence variation at the microtubule-associated protein tau (MAPT) locus and MAPT expression in the brain, providing an exciting new paradigm for the field.
引用
收藏
页码：477 / 478
页数：2
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