Synthesis of 3-oxoalkylphosphonates via the conjugate addition of acylcuprates to diethyl vinylphosphonate

被引：11
|
作者：
Li, NS
Yu, S
Kabalka, GW [1 ]
机构：
[1] Univ Tennessee, Dept Chem, Knoxville, TN 37996 USA
[2] Univ Tennessee, Dept Radiol, Knoxville, TN 37996 USA
来源：
ORGANOMETALLICS | 1999年 / 18卷 / 09期
关键词：
D O I：
10.1021/om980995i
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Acylcuprate reagents generated by the reaction of dialkylcyanocuprates with carbon monoxide at low temperature (-110 degrees C) readily react with diethyl vinylphosphonate to give 3-oxoalkylphosphonates in good yields after hydrolysis. The reaction intermediates can also be trapped by allylic bromides to give 1-allyl-3-oxo-alkylphosphonates in good yields.
引用
收藏
页码：1811 / 1814
页数：4
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