Biochemical premotor biomarkers for Parkinson's disease

被引：28
|
作者：
Mollenhauer, Brit [1 ,2 ]
Zhang, Jing [3 ]
机构：
[1] Paracelsus Elena Klin, D-34128 Kassel, Germany
[2] Univ Gottingen, Kassel, Germany
[3] Univ Washington, Dept Pathol, Seattle, WA 98195 USA
来源：
MOVEMENT DISORDERS | 2012年 / 27卷 / 05期
关键词：
biomarkers; genomics; metabolomics; Parkinson's disease; premotor; proteomics; HUMAN CEREBROSPINAL-FLUID; ALPHA-SYNUCLEIN; GENE-EXPRESSION; URIC-ACID; ALZHEIMER; PROTEIN; URATE; DJ-1; CSF; PROTEOMICS;
D O I：
10.1002/mds.24956
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
A biomarker is a biological characteristic that is objectively measured and evaluated as an indicator of normal biological or pathologic processes or of pharmacologic responses to a therapeutic intervention. We reviewed the current status of target protein biomarkers (eg, total/oligomeric a-synuclein and DJ-1) in cerebrospinal fluid, as well as on unbiased processes that can be used to discover novel biomarkers. We have also provide ddetails about strategies toward potential populations/models and technologies, including the need for standardized sampling techniques, to pursue the identification of new biochemical markers in the premotor stage of Parkinson's disease in the future. (C) 2012 Movement Disorder Society
引用
收藏
页码：644 / 650
页数：7
相关论文
共 50 条
  • [21] Overactivity of cervical premotor neurons in Parkinson's disease
    Pol, S
    Vidailhet, M
    Meunier, S
    Mazevet, D
    Agid, Y
    Pierrot-Deseilligny, E
    JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1998, 64 (02): : 166 - 171
  • [22] Dissecting premotor Parkinson's disease with multimodality neuroimaging
    Iranzo, Alex
    LANCET NEUROLOGY, 2018, 17 (07): : 574 - 576
  • [23] Before the Tremor Premotor Symptoms of Parkinson's Disease
    Konkel, Lindsey
    ENVIRONMENTAL HEALTH PERSPECTIVES, 2013, 121 (11-12) : A342 - A342
  • [24] TRANSCRANIAL SONOGRAPHY IN THE PREMOTOR DIAGNOSIS OF PARKINSON'S DISEASE
    Behnke, Stefanie
    Schroeder, Ute
    Berg, Daniela
    TRANSCRANIAL SONOGRAPHY IN MOVEMENT DISORDERS, 2010, 90 : 93 - 106
  • [25] Lewy pathology and neurodegeneration in premotor Parkinson's disease
    Del Tredici, Kelly
    Braak, Heiko
    MOVEMENT DISORDERS, 2012, 27 (05) : 597 - 607
  • [26] Biomarkers in Parkinson's Disease
    Morgan, John C.
    Mehta, Shyamal H.
    Sethi, Kapil D.
    CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS, 2010, 10 (06) : 423 - 430
  • [27] Biomarkers for Parkinson's Disease
    Sherer, Todd B.
    SCIENCE TRANSLATIONAL MEDICINE, 2011, 3 (79)
  • [28] Biomarkers and Parkinson's disease
    Michell, AW
    Lewis, SJG
    Foltynie, T
    Barker, RA
    BRAIN, 2004, 127 : 1693 - 1705
  • [29] Biomarkers in Parkinson’s Disease
    John C. Morgan
    Shyamal H. Mehta
    Kapil D. Sethi
    Current Neurology and Neuroscience Reports, 2010, 10 : 423 - 430
  • [30] BIOMARKERS OF PARKINSON'S DISEASE
    Kondybayeva, A.
    Aralbayeva, A.
    Kamenova, S.
    Akimniyazova, A.
    Pyrkova, A.
    Ivashchenko, A.
    Kuzhybayeva, K.
    PARKINSONISM & RELATED DISORDERS, 2023, 113 : 27 - 27
12345