Biochemical premotor biomarkers for Parkinson's disease

被引：28

作者：

Mollenhauer, Brit ^{[1
,2
]}

Zhang, Jing ^{[3
]}

机构：

[1] Paracelsus Elena Klin, D-34128 Kassel, Germany

[2] Univ Gottingen, Kassel, Germany

[3] Univ Washington, Dept Pathol, Seattle, WA 98195 USA

来源：

MOVEMENT DISORDERS | 2012年 / 27卷 / 05期

关键词：

biomarkers; genomics; metabolomics; Parkinson's disease; premotor; proteomics; HUMAN CEREBROSPINAL-FLUID; ALPHA-SYNUCLEIN; GENE-EXPRESSION; URIC-ACID; ALZHEIMER; PROTEIN; URATE; DJ-1; CSF; PROTEOMICS;

D O I：

10.1002/mds.24956

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A biomarker is a biological characteristic that is objectively measured and evaluated as an indicator of normal biological or pathologic processes or of pharmacologic responses to a therapeutic intervention. We reviewed the current status of target protein biomarkers (eg, total/oligomeric a-synuclein and DJ-1) in cerebrospinal fluid, as well as on unbiased processes that can be used to discover novel biomarkers. We have also provide ddetails about strategies toward potential populations/models and technologies, including the need for standardized sampling techniques, to pursue the identification of new biochemical markers in the premotor stage of Parkinson's disease in the future. (C) 2012 Movement Disorder Society

引用

页码：644 / 650

页数：7

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