DNA-binding and cleavage studies of chiral Mn(III) salen complexes

被引：28

作者：

Peng, Bin ^{[1
]}

Zhou, Wen-Hui ^{[1
]}

Yan, Lin ^{[1
]}

Liu, Han-Wen ^{[1
]}

Zhu, Li ^{[1
]}

机构：

[1] Hunan Univ Sci & Technol, Sch Chem & Chem Engn, Xiangtan 411201, Peoples R China

来源：

TRANSITION METAL CHEMISTRY | 2009年 / 34卷 / 02期

关键词：

DEOXYRIBONUCLEIC-ACID; FLUORESCENCE;

D O I：

10.1007/s11243-008-9183-7

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Chiral bridge-substituted manganese(III) complexes of N,N'-bis-(2-hydroxynaphthalene-1-carbaldehyde)-(1R,2R)-(-)-diaminocyclohexane and N,N'-bis-(2-hydroxynaphthalene-1-carbaldehyde)-(1S,2S)-(+)-diaminocyclohexane have been synthesized. The interaction of these complexes with calf thymus DNA(CT-DNA) was investigated by spectroscopic, thermal denaturation studies, circular dichroism (CD), and viscosity measurements. Results of spectroscopic and viscosity measurements suggest that the two complexes bind to DNA via an intercalative mode and display enantioselectivity. These Mn(III) complexes have been found to promote the cleavage of plasmid DNA pBR322 in the presence of H(2)O(2).

引用

页码：231 / 237

页数：7

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