An Integrative Multiscale Modeling Approach for the Study of Tinnitus Decompensation Neural Correlates

The study of tinnitus has become of great interest due to the increasing number and severity of cases reported worldwide. To cope with such situation, many experimental and theoretical studies have been dedicated to gain deeper insight into the neurophysiological mechanisms involved in the tinnitus decompensation. In this direction, some of the most influential tinnitus models have emphasized the link between selective attention and the tinnitus decompensation. However, it is still not clear what are the mechanisms involved in such relation and wether it is possible to provide a neuropsychological framework linking them with respect to large-scale neural correlates. In order to address such issues, we make use of evoked cortical potential neural correlates of auditory selective attention. We thus propose an integrative multiscale modeling approach for large-scale neural correlates of selective attention in the tinnitus decompensation. The results of our simulations are compared with experimental data so that hypothesis can be validated.