Overexpression of the transmembrane carbonic anhydrase isoforms IX and XII in the inflamed synovium

被引：81

作者：

Margheri, Francesca ^{[1
]}

Ceruso, Mariangela ^{[2
]}

Carta, Fabrizio ^{[2
]}

Laurenzana, Anna ^{[1
]}

Maggi, Laura ^{[3
]}

Lazzeri, Simone ^{[4
,5
]}

Simonini, Gabriele ^{[2
,4
,5
]}

Annunziato, Francesco ^{[3
]}

Del Rosso, Mario ^{[1
]}

Supuran, Claudiu T. ^{[2
]}

Cimaz, Rolando ^{[2
,4
,5
]}

机构：

[1] Univ Florence, Dept Expt & Clin Biomed Sci, Florence, Italy

[2] Univ Florence, Neurofarba Dept, Via U Schiff 6, I-50019 Florence, Italy

[3] Univ Florence, Dept Expt & Clin Med, Florence, Italy

[4] Anna Meyer Childrens Hosp, Florence, Italy

[5] Univ Florence, Viale Pieraccini 24, I-50139 Florence, Italy

来源：

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2016年 / 31卷

关键词：

Carbonic anhydrase; juvenile idiopathic arthritis; synovium; INHIBITORS; FLUID; PH;

D O I：

10.1080/14756366.2016.1217857

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Juvenile idiopathic arthritis (JIA) is the most common form of chronic rheumatic disease affecting children worldwide, with some features similar to adult rheumatoid arthritis (RA). In the present study, we aim at investigating novel markers that will allow in the future for tailored, more personalized treatment strategies. Hence, taking notice of several reports proving the role of local acidosis as a causal link between inflammatory diseases and related pain, and the involvement of several carbonic anhydrases (CA, EC 4.2.1.1) isoforms in articular diseases, we evaluated in JIA patients the expression of these metalloenzymes. We identified that JIA patients show high levels of active CA IX and XII isoforms. Our results represent the first evidence of the identification of these enzymes as potential therapeutic targets and development of novel innovative therapies for arthritis, also considering that the two isoforms are validated antitumor targets.

引用

页码：60 / 63

页数：4

共 50 条

[31] Selective inhibition of carbonic anhydrase IX and XII by coumarin and psoralen derivatives
Meleddu, Rita
Deplano, Serenella
Maccioni, Elias
Ortuso, Francesco
Cottiglia, Filippo
Secci, Daniela
Onali, Alessia
Sanna, Erica
Angeli, Andrea
Angius, Rossella
Alcaro, Stefano
Supuran, Claudiu T.
Distinto, Simona
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2021, 36 (01) : 685 - 692
[32] Ureidosulfocoumarin Derivatives As Selective and Potent Carbonic Anhydrase IX and XII Inhibitors
Singh, Priti
Kumar Sigalapalli, Dilep
Sridhar Goud, Nerella
Swain, Baijayantimala
Kumar Sahoo, Santosh
Angeli, Andrea
Shaik, Afzal B.
Madhavi Yaddanapudi, Venkata
Supuran, Claudiu T.
Arifuddin, Mohammed
CHEMMEDCHEM, 2022, 17 (05)
[33] Isocoumarins: a new class of selective carbonic anhydrase IX and XII inhibitors
Onyilmaz, Mehmet
Koca, Murat
Bonardi, Alessandro
Degirmenci, Mustafa
Supuran, Claudiu T.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2022, 37 (01) : 743 - 748
[34] Carbonic anhydrase enzymes II, VII, IX and XII in colorectal carcinomas
Viikila, Pia
Kivela, Antti J.
Mustonen, Harri
Koskensalo, Selja
Waheed, Abdul
Sly, William S.
Pastorek, Jaromir
Pastorekova, Silvia
Parkkila, Seppo
Haglund, Caj
WORLD JOURNAL OF GASTROENTEROLOGY, 2016, 22 (36) : 8168 - 8177
[35] Attachment of carbohydrates to methoxyaryl moieties leads to highly selective inhibitors of the cancer associated carbonic anhydrase isoforms IX and XII
Riafrecha, Leonardo E.
Rodriguez, Oscar M.
Vullo, Daniela
Supuran, Claudiu T.
Colinas, Pedro A.
BIOORGANIC & MEDICINAL CHEMISTRY, 2014, 22 (19) : 5308 - 5314
[36] Selenium-analogs based on natural sources as cancer-associated carbonic anhydrase isoforms IX and XII inhibitors
Astrain-Redin, Nora
Paoletti, Niccolo
Plano, Daniel
Bonardi, Alessandro
Gratteri, Paola
Angeli, Andrea
Sanmartin, Carmen
Supuran, Claudiu T.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2023, 38 (01)
[37] Carbonic anhydrase inhibitors:: Bioreductive nitro-containing Sulfonamides with selectivity for targeting the tumor associated isoforms IX and XII
D'Ambrosio, Katia
Vitale, Rosa-Maria
Dogne, Jean-Michel
Masereel, Bernard
Innocenti, Alessio
Scozzafava, Andrea
De Simone, Giuseppina
Supuran, Claudiu T.
JOURNAL OF MEDICINAL CHEMISTRY, 2008, 51 (11) : 3230 - 3237
[38] Discovery of 2,4-thiazolidinedione-tethered coumarins as novel selective inhibitors for carbonic anhydrase IX and XII isoforms
Eldehna, Wagdy M.
Taghour, Mohammed S.
Al-Warhi, Tarfah
Nocentini, Alessio
Elbadawi, Mostafa M.
Mahdy, Hazem A.
Abdelrahman, Mohamed A.
Alotaibi, Ohoud J.
Aljaeed, Nada
Elimam, Diaaeldin M.
Afarinkia, Kamyar
Abdel-Aziz, Hatem A.
Supuran, Claudiu T.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2022, 37 (01) : 531 - 541
[39] Discovery of curcumin inspired sulfonamide derivatives as a new class of carbonic anhydrase isoforms I, II, IX, and XII inhibitors
Ramya, P. V. Sri
Angapelly, Srinivas
Angeli, Andrea
Digwal, Chander Singh
Arifuddin, Mohammed
Babu, Bathini Nagendra
Supuran, Claudiu T.
Kamal, Ahmed
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2017, 32 (01) : 1274 - 1281
[40] Effect of incorporating a thiophene tail in the scaffold of acetazolamide on the inhibition of human carbonic anhydrase isoforms I, II, IX and XII
Biswas, Shyamasri
McKenna, Robert
Supuran, Claudiu T.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2013, 23 (20) : 5646 - 5649

← 1 2 3 4 5 →