In vitro anti-inflammatory activity of lignans isolated from Magnolia fargesii

被引：73

作者：

Kim, Jae Yeon ^{[1
]}

Lim, Hyo Jin ^{[1
]}

Lee, Da Yeon ^{[1
]}

Kim, Ji Sun ^{[1
]}

Kim, Do Hee ^{[1
]}

Lee, Hwa Jin ^{[1
]}

Kim, Hee Doo ^{[1
]}

Jeon, Raok ^{[1
]}

Ryu, Jae-Ha ^{[1
]}

机构：

[1] Sookmyung Womens Univ, Coll Pharm, Seoul 140742, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 03期

关键词：

Magnolia fargesii; Nitric oxide; Prostaglandin E-2; Microglia; NITRIC-OXIDE SYNTHASES; FLOWER BUDS; SELECTIVE INHIBITOR; FLOS-MAGNOLIAE; LIPOPOLYSACCHARIDE; STEREOCHEMISTRY; EXPRESSION; CYCLOOXYGENASE-2; DERIVATIVES; ASSIGNMENT;

D O I：

10.1016/j.bmcl.2008.11.103

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The overproduction of nitric oxide (NO) and prostaglandin E-2 (PGE(2)) causes neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. Four lignans, (+)-eudesmin (1), (+)-magnolin (2), (+)yangambin (3) and a new structure named as epimagnolin B (4) were isolated from Magnolia fargesii (Magnoliaceae) as the inhibitors of NO production in LPS-activated microglia. The most potent compound 4 inhibited the production of NO and PGE(2) and the expression of respective enzyme iNOS and COX-2 through the suppression of I-kappa B-alpha degradation and nuclear translocation of p65 subunit of NF-kappa B. (C) 2009 Published by Elsevier Ltd.

引用

页码：937 / 940

页数：4

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