Nanostructured Hydroxyapatite-Chitosan Composite Biomaterial for Bone Tissue engineering

In the recent years, significant developments have been achieved with chitosan and hydroxyapatite (HAp) scaffolds for bone tissue engineering. In the present study, chitosan/nanostructured hydroxyapatite (Chitosan/nHAp) has been prepared and subsequently characterized physicochemically for bone graft substitution. The nano sized HAp particles were uniformly distributed in the chitosan matrix, which was confirmed, by Fourier Transform Infrared Spectroscopy, Thermal Gravimetric Analysis, X-Ray Diffraction and Scanning Electron Microscopy analysis. The pore size of the chitosan/nHAp scaffold was found to be 18-372 mu m which is suitable for cell attachment and nutrient supplement. Thus, we are suggesting that Chitosan/nHAp could be promising biomaterials for bone tissue engineering.