Comparisons of pathologic and normal skin reactive autoantibodies and the interference phenomenon

被引：3
|
作者：
Beutner, Ernst H. [1 ,2 ,3 ]
Grover, Raminder K. [1 ,2 ]
Plunkett, Richard W. [1 ,2 ]
Lewis, Michelle E. [1 ]
机构：
[1] Beutner Labs Inc, Buffalo, NY 14215 USA
[2] SUNY Buffalo, Sch Med, Dept Microbiol & Immunol, Buffalo, NY 14214 USA
[3] SUNY Buffalo, Sch Med, Dept Dermatol, Buffalo, NY 14214 USA
来源：
CLINICS IN DERMATOLOGY | 2012年 / 30卷 / 04期
关键词：
D O I：
10.1016/j.clindermatol.2012.03.001
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Immunofluorescent serum studies of the roles of the two groups of normal complement-fixing autoantibodies in psoriasis are complicated by the interference phenomenon. Both antibodies have the potential to react in vivo at sites of trauma and in psoriasiform lesions. In serum tests, only one or the other reacts, as demonstrated by immunofluorescent serum tests and absorption studies with isolated stratum corneum antigen. In tests of 15 normal sera, only one consistently reacted with the soluble carbohydrate antigens; the rest consistently reacted with the glycoproteins of the keratin intermediate filaments. This appears to be due to an antibody interference reaction that permits only one of two or more antibodies to react on a given tissue section. (C) 2012 Elsevier Inc. All rights reserved.
引用
收藏
页码：447 / 449
页数：3
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