Isolation and Complete Genome Sequencing of Zika Virus Imported from the Dominican Republic to Japan

被引：2
|
作者：
Ozawa, Hiroki [1 ]
Tajima, Shigeru [2 ]
Nakayama, Eri [2 ]
Kato, Kengo [3 ]
Yamashita, Akifumi [3 ]
Sekizuka, Tsuyoshi [3 ]
Kuroda, Makoto [3 ]
Usuku, Shuzo [1 ]
机构：
[1] Yokohama City Inst Publ Hlth, Dept Microbiol Testing & Res, Kanazawa Ku, Tomiokahigashi 2-7-1, Yokohama, Kanagawa 2360051, Japan
[2] Dept Virol 1, 1-23-1 Toyama, Tokyo 1628640, Japan
[3] Natl Inst Infect Dis, Pathogen Genom Ctr, Shinjuku Ku, 1-23-1 Toyama, Tokyo 1628640, Japan
来源：
JAPANESE JOURNAL OF INFECTIOUS DISEASES | 2018年 / 71卷 / 01期
关键词：
D O I：
10.7883/yoken.JJID.2017.256
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Zika virus (ZIKV) infection has been documented within Central and South America, Asia, and Africa. Here we report the isolation of virus from a patient infected with ZIKV returning to Japan from the Dominican Republic. The ZIKV strain was imaged by electron microscopy and its complete genome sequence was analyzed. Phylogenetic analysis and molecular characterization revealed that the strain was of Asian lineage, and carried 2 unique mutations in its NS5 region. These mutations are characteristic of strains that originated in the Dominican Republic and the USA in 2016.
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页码：72 / 74
页数：3
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