GENETICS Fish heads and human disease

被引:2
|
作者
Malhotra, Dheeraj [1 ,2 ]
Sebat, Jonathan [1 ,2 ,3 ,4 ]
机构
[1] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA
[2] Univ Calif San Diego, Dept Cellular & Mol Med, La Jolla, CA 92093 USA
[3] Univ Calif San Diego, Inst Genom Med, San Diego, CA 92103 USA
[4] Univ Calif San Diego, Beyster Ctr Genom Psychiat Dis, San Diego, CA 92103 USA
关键词
CHROMOSOME; 16P11.2; PHENOTYPES; DELETIONS; PROTEIN; OBESITY; AUTISM; DOSAGE;
D O I
10.1038/485318a
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The expression level of a single gene can determine head size in zebrafish, mirroring a human anatomical feature associated with neurological disorders such as autism and schizophrenia. See Letter p.363
引用
收藏
页码:318 / 319
页数:2
相关论文
共 50 条
  • [41] GENETICS Human genome editing in heart disease
    Lim, Gregory B.
    NATURE REVIEWS CARDIOLOGY, 2017, 14 (10) : 567 - 567
  • [42] The genetics of human hematopoiesis and its disruption in disease
    Bao, Erik L.
    Cheng, Aaron N.
    Sankaran, Vijay G.
    EMBO MOLECULAR MEDICINE, 2019, 11 (08)
  • [43] The genomics and genetics of human infectious disease susceptibility
    Hill, AVS
    ANNUAL REVIEW OF GENOMICS AND HUMAN GENETICS, 2001, 2 : 373 - 400
  • [44] MOLECULAR-GENETICS AND HUMAN-DISEASE
    DAVID, AS
    BRITISH JOURNAL OF PSYCHIATRY, 1989, 154 : 119 - 119
  • [45] Harnessing the mouse to unravel the genetics of human disease
    Phillips, TJ
    Belknap, JK
    Hitzemann, RJ
    Buck, KJ
    Cunningham, CL
    Crabbe, JC
    GENES BRAIN AND BEHAVIOR, 2002, 1 (01) : 14 - 26
  • [46] Applications of comparative evolution to human disease genetics
    McWhite, Claire D.
    Liebeskind, Benjamin J.
    Marcotte, Edward M.
    CURRENT OPINION IN GENETICS & DEVELOPMENT, 2015, 35 : 16 - 24
  • [47] Model Organisms Illuminate Human Genetics and Disease
    Veronica van Heyningen
    Molecular Medicine, 1997, 3 : 231 - 237
  • [48] Genetics of human congenital urinary bladder disease
    Adrian S. Woolf
    Helen M. Stuart
    William G. Newman
    Pediatric Nephrology, 2014, 29 : 353 - 360
  • [49] Model organisms illuminate human genetics and disease
    vanHeyningen, V
    MOLECULAR MEDICINE, 1997, 3 (04) : 231 - 237
  • [50] Human genetics illuminates the paths to metabolic disease
    Stephen O’Rahilly
    Nature, 2009, 462 : 307 - 314