Biological and therapeutic activities of thymoquinone: Focus on the Nrf2 signaling pathway

被引：38
|
作者：
Talebi, Marjan [1 ]
Talebi, Mohsen [2 ,3 ]
Farkhondeh, Tahereh [4 ,5 ]
Samarghandian, Saeed [6 ]
机构：
[1] Shahid Beheshti Univ Med Sci, Sch Pharm, Dept Pharmacognosy & Pharmaceut Biotechnol, Tehran, Iran
[2] Univ Texas Arlington, Dept Chem & Biochem, Arlington, TX 76019 USA
[3] Mylan Pharmaceut Inc, San Antonio, TX USA
[4] Birjand Univ Med Sci BUMS, Med Toxicol & Drug Abuse Res Ctr MTDRC, Birjand, Iran
[5] Birjand Univ Med Sci, Fac Pharm, Birjand, Iran
[6] Neyshabur Univ Med Sci, Noncommunicable Dis Res Ctr, Neyshabur, Iran
来源：
PHYTOTHERAPY RESEARCH | 2021年 / 35卷 / 04期
关键词：
inflammation; nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway; oxidative stress; therapeutic effects; thymoquinone; NIGELLA-SATIVA L; HEME OXYGENASE-1 EXPRESSION; TRANSCRIPTION FACTOR NRF2; SYNTHASE KINASE-3 GSK3; OXIDATIVE STRESS; CANCER CHEMOPREVENTION; CHEMICAL-COMPOSITION; ADAPTIVE RESPONSE; ESSENTIAL OIL; TOXICITY;
D O I：
10.1002/ptr.6905
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Thymoquinone is a monoterpenoid compound, which is derived from volatile and fixed oil ofNigella sativa(Ranunculaceae). This phytochemical compound has several biological effects, including antioxidant, antibacterial, antineoplastic, nephroprotective, hepatoprotective, gastroprotective, neuroprotective, anti-nociceptive, and anti-inflammatory activities. Thymoquinone shows pharmacological activities, including anti-hepatocellular carcinoma, nephroprotection, neuroprotection, retina protection, gastroprotection, cardioprotection, anti-allergy, reproductive system protection, bladder protection, and respiratory protection. It was found that these beneficial effects are mostly related to modulation of the Nrf2 signaling pathway by blockage of Keap1, stimulating the expression of the Nrf2 gene, and inducing the nuclear translocation of Nrf2. In the present review, the therapeutic effects of thymoquinone are overviewed through the Nrf2 signaling pathway.
引用
收藏
页码：1739 / 1753
页数：15
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