Core-Shell Hydrogel Microcapsules for Improved Islets Encapsulation

被引：128

作者：

Ma, Minglin ^{[1
,4
]}

Chiu, Alan ^{[1
,4
]}

Sahay, Gaurav ^{[1
]}

Doloff, Joshua C. ^{[1
,4
]}

Dholakia, Nimit ^{[1
,4
]}

Thakrar, Raj ^{[1
,4
]}

Cohen, Joshua ^{[5
]}

Vegas, Arturo ^{[1
,4
]}

Chen, Delai ^{[1
,4
]}

Bratlie, Kaitlin M. ^{[6
,7
]}

Dang, Tram ^{[1
,4
]}

York, Roger L. ^{[1
,4
]}

Hollister-Lock, Jennifer ^{[5
]}

Weir, Gordon C. ^{[5
]}

Anderson, Daniel G. ^{[1
,2
,3
,4
,5
]}

机构：

[1] MIT, David H Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA

[2] MIT, Dept Chem Engn, Cambridge, MA 02139 USA

[3] MIT, Div Hlth Sci Technol, Cambridge, MA 02139 USA

[4] Childrens Hosp, Dept Anesthesiol, Boston, MA 02115 USA

[5] Joslin Diabet Ctr, Sect Islet Cell & Regenerat Biol, Div Res, Boston, MA 02215 USA

[6] Iowa State Univ, Dept Mat Sci & Engn, Ames, IA 50011 USA

[7] Iowa State Univ, Dept Chem & Biol Engn, Ames, IA 50011 USA

来源：

ADVANCED HEALTHCARE MATERIALS | 2013年 / 2卷 / 05期

基金：

美国国家卫生研究院;

关键词：

Islets encapsulation; transplantation; core-shell structures; immuno-protection; microcapsules; hydrogels; TYPE-1; DIABETES-MELLITUS; ALGINATE MICROCAPSULES; PANCREATIC-ISLETS; PORCINE ISLETS; NONIMMUNOSUPPRESSED PATIENTS; GRAFT IMMUNOPROTECTION; IN-VITRO; CELLS; IMMUNOISOLATION; MICROENCAPSULATION;

D O I：

10.1002/adhm.201200341

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Islets microencapsulation holds great promise to treat type 1 diabetes. Currently used alginate microcapsules often have islets protruding outside capsules, leading to inadequate immuno-protection. A novel design of microcapsules with core-shell structures using a two-fluid co-axial electro-jetting is reported. Improved encapsulation and diabetes correction is achieved in a single step by simply confining the islets in the core region of the capsules. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：667 / 672

页数：6

共 50 条

[21] Cell encapsulation in core-shell microcapsules through coaxial electrospinning system and horseradish peroxidase-catalyzed crosslinking
Khanmohammadi, Mehdi
Zolfagharzadeh, Vahid
Bagher, Zohreh
Soltani, Hadi
Ai, Jafar
BIOMEDICAL PHYSICS & ENGINEERING EXPRESS, 2020, 6 (01)
[22] Core-shell nanoparticles for co-encapsulation of coenzyme Q10 and piperine: Surface engineering of hydrogel shell around protein core
Chen, Shuai
Zhang, Yanhui
Qing, Jing
Han, Yahong
McClements, David Julian
Gao, Yanxiang
FOOD HYDROCOLLOIDS, 2020, 103
[23] Novel encapsulation technology for the preparation of core-shell microparticles
ten Cate, A. T.
Pieterse, G.
Eversdijk, J.
Brouwers, L. A. M.
Craenmehr, E. G. M.
van Ee, R. J.
Rijfers, A.
Papen-Botterhuis, N. E.
Houben, R. J.
van Bommel, K. J. C.
JOURNAL OF CONTROLLED RELEASE, 2010, 148 (01) : E8 - E9
[24] Preparation of core-shell polymer colloid particles by encapsulation
Ottewill, RH
Schofield, AB
Waters, JA
Williams, NSJ
COLLOID AND POLYMER SCIENCE, 1997, 275 (03) : 274 - 283
[25] Formation of core-shell droplets for the encapsulation of liquid contents
Galogahi, Fariba Malekpour
Zhu, Yong
An, Hongjie
Nam-Trung Nguyen
MICROFLUIDICS AND NANOFLUIDICS, 2021, 25 (10)
[26] Preparation of core-shell polymer colloid particles by encapsulation
R. H. Ottewill
A. B. Schofield
J. A. Waters
N. St. J. Williams
Colloid and Polymer Science, 1997, 275 : 274 - 283
[27] Core-shell micro/nanocapsules: from encapsulation to applications
Elkalla, Eslam
Khizar, Sumera
Tarhini, Mohamad
Lebaz, Noureddine
Zine, Nadia
Jaffrezic-Renault, Nicole
Errachid, Abdelhamid
Elaissari, Abdelhamid
JOURNAL OF MICROENCAPSULATION, 2023, 40 (03) : 125 - 156
[28] Core-shell hydrogel microcapsules enable formation of human pluripotent stem cell spheroids and their cultivation in a stirred bioreactor
Fattahi, Pouria
Rahimian, Ali
Slama, Michael Q.
Gwon, Kihak
Gonzalez-Suarez, Alan M.
Wolf, Jadon
Baskaran, Harihara
Duffy, Caden D.
Stybayeva, Gulnaz
Peterson, Quinn P.
Revzin, Alexander
SCIENTIFIC REPORTS, 2021, 11 (01)
[29] Visual Indication of Mechanical Damage Using Core-Shell Microcapsules
Odom, Susan A.
Jackson, Aaron C.
Prokup, Alex M.
Chayanupatkul, Sarut
Sottos, Nancy R.
White, Scott R.
Moore, Jeffrey S.
ACS APPLIED MATERIALS & INTERFACES, 2011, 3 (12) : 4547 - 4551
[30] Chemiluminescence emission in cholesteric liquid crystalline core-shell microcapsules
Iwai, Y.
Kaji, H.
Uchida, Y.
Nishiyama, N.
JOURNAL OF MATERIALS CHEMISTRY C, 2014, 2 (25) : 4904 - 4908

← 1 2 3 4 5 →