Core-Shell Hydrogel Microcapsules for Improved Islets Encapsulation

被引：128

作者：

Ma, Minglin ^{[1
,4
]}

Chiu, Alan ^{[1
,4
]}

Sahay, Gaurav ^{[1
]}

Doloff, Joshua C. ^{[1
,4
]}

Dholakia, Nimit ^{[1
,4
]}

Thakrar, Raj ^{[1
,4
]}

Cohen, Joshua ^{[5
]}

Vegas, Arturo ^{[1
,4
]}

Chen, Delai ^{[1
,4
]}

Bratlie, Kaitlin M. ^{[6
,7
]}

Dang, Tram ^{[1
,4
]}

York, Roger L. ^{[1
,4
]}

Hollister-Lock, Jennifer ^{[5
]}

Weir, Gordon C. ^{[5
]}

Anderson, Daniel G. ^{[1
,2
,3
,4
,5
]}

机构：

[1] MIT, David H Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA

[2] MIT, Dept Chem Engn, Cambridge, MA 02139 USA

[3] MIT, Div Hlth Sci Technol, Cambridge, MA 02139 USA

[4] Childrens Hosp, Dept Anesthesiol, Boston, MA 02115 USA

[5] Joslin Diabet Ctr, Sect Islet Cell & Regenerat Biol, Div Res, Boston, MA 02215 USA

[6] Iowa State Univ, Dept Mat Sci & Engn, Ames, IA 50011 USA

[7] Iowa State Univ, Dept Chem & Biol Engn, Ames, IA 50011 USA

来源：

ADVANCED HEALTHCARE MATERIALS | 2013年 / 2卷 / 05期

基金：

美国国家卫生研究院;

关键词：

Islets encapsulation; transplantation; core-shell structures; immuno-protection; microcapsules; hydrogels; TYPE-1; DIABETES-MELLITUS; ALGINATE MICROCAPSULES; PANCREATIC-ISLETS; PORCINE ISLETS; NONIMMUNOSUPPRESSED PATIENTS; GRAFT IMMUNOPROTECTION; IN-VITRO; CELLS; IMMUNOISOLATION; MICROENCAPSULATION;

D O I：

10.1002/adhm.201200341

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Islets microencapsulation holds great promise to treat type 1 diabetes. Currently used alginate microcapsules often have islets protruding outside capsules, leading to inadequate immuno-protection. A novel design of microcapsules with core-shell structures using a two-fluid co-axial electro-jetting is reported. Improved encapsulation and diabetes correction is achieved in a single step by simply confining the islets in the core region of the capsules. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：667 / 672

页数：6

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