Polymerase theta inhibition synergizes with anti-PD-1 immunotherapy in BRCA2-deficient pancreatic ductal adenocarcinoma.

被引：0
|
作者：
Patterson-Fortin, Jeffrey [1 ]
Jadhav, Heta [1 ]
Pantelidou, Constantia [2 ]
Phan, Tin [1 ]
Grochala, Carter [1 ]
Hao, Jie [1 ]
Wang, Junning [1 ]
Andrews, Elizabeth A. [1 ]
Guerriero, Jennifer L. [3 ]
Wolpin, Brian M. [1 ]
Stanger, Ben Z. [4 ]
Aguirre, Andrew A. [1 ]
Cleary, James M. [1 ]
D'Andrea, Alan A. [1 ]
Shapiro, Geoffrey I. [1 ]
机构：
[1] Dana Farber Canc Inst, Boston, MA 02115 USA
[2] Bayer US LLC, Pharmaceut, Boston, MA USA
[3] Brigham & Womens Hosp, Dept Surg, Div Breast Surg, 75 Francis St, Boston, MA 02115 USA
[4] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA
来源：
CANCER RESEARCH | 2022年 / 82卷 / 22期
关键词：
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
C010
引用
收藏
页码：117 / 118
页数：2
相关论文
共 50 条
  • [31] A Clinicopathologic and Molecular Study of BRCA1/2-mutated Pancreatic Ductal Adenocarcinoma
    Li, Hongjie
    Gibson, Joanna
    Jain, Dhanpat
    Finberg, Karin
    Walther, Zenta
    Zhong, Minghao
    MODERN PATHOLOGY, 2021, 34 (SUPPL 2) : 1050 - 1051
  • [32] Single-cell RNA sequencing to characterize the response of pancreatic cancer to anti-PD-1 immunotherapy
    Zhou, Jing
    Jiang, Yuexu
    Huang, Yue
    Wang, Qiongling
    Kaifi, Jussuf T. T.
    Kimchi, Eric T. T.
    Liu, Zhenguo
    Joshi, Trupti
    Li, Guangfu
    Chabu, Chiswili Yves
    TRANSLATIONAL ONCOLOGY, 2022, 15 (01):
  • [33] COMBINED COX-2 INHIBITION WITH FISH OIL AND ASPIRIN AS ADJUNCTS TO ANTI-PD-1 IMMUNOTHERAPY IN METASTATIC MELANOMA
    Chacon, Alexander
    Melucci, Alexa
    Qin, Shuyang
    Burchard, Paul
    Jackson, Katherine
    Jewell, Rachel
    Prieto, Peter
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2021, 9 : A311 - A311
  • [34] Efficient deletion of normal Brca2-deficient intestinal epithelium by poly(ADP-ribose) polymerase inhibition models potential prophylactic therapy
    Hay, T
    Jenkins, H
    Sansom, OJ
    Martin, NMB
    Smith, GCM
    Clarke, AR
    CANCER RESEARCH, 2005, 65 (22) : 10145 - 10148
  • [35] Influence of type 2 diabetes mellitus and concomitant anti-diabetic medications in patients with metastatic pancreatic ductal adenocarcinoma.
    Pretta, Andrea
    Cimbro, Erika
    Giampieri, Riccardo
    Spanu, Dario
    Lai, Eleonora
    Pecci, Federica
    Balconi, Francesca
    Lupi, Alessio
    Pozzari, Marta
    Murgia, Sara
    Bardanzellu, Fabio
    Maccioni, Antonio
    Contu, Fabiana
    Persano, Mara
    Donisi, Clelia
    Pusceddu, Valeria
    Puzzoni, Marco
    Ziranu, Pina
    Berardi, Rossana
    Scartozzi, Mario
    JOURNAL OF CLINICAL ONCOLOGY, 2022, 40 (16) : E16301 - E16301
  • [36] 5-Hydroxymethyl-2′-deoxyuridine, but not temozolomide, enhances the selective synthetic lethality in BRCA1 and BRCA2-deficient cells caused by PARP inhibition
    Clement, Jean
    Nakamura, Jun
    CANCER RESEARCH, 2013, 73 (08)
  • [37] Targeting leucine-rich repeat serine/threonine- protein kinase 2 sensitizes pancreatic ductal adenocarcinoma to anti-PD-L1 immunotherapy
    Sun, Kang
    Zhang, Xiaozhen
    Lao, Mengyi
    He, Lihong
    Wang, Sicheng
    Yang, Hanshen
    Xu, Jian
    Tang, Jianghui
    Hong, Zhengtao
    Song, Jinyuan
    Guo, Chengxiang
    Li, Muchun
    Liu, Xinyuan
    Chen, Yan
    Zhang, Hanjia
    Zhou, Jingxing
    Lin, Jieru
    Zhang, Sirui
    Hong, Yifan
    Huang, Jinyan
    Liang, Tingbo
    Bai, Xueli
    MOLECULAR THERAPY, 2023, 31 (10) : 2929 - 2947
  • [38] Targeting DDR2 enhances tumor response to anti-PD-1 immunotherapy
    Tu, Megan M.
    Lee, Francis Y. F.
    Jones, Robert T.
    Kimball, Abigail K.
    Saravia, Elizabeth
    Graziano, Robert F.
    Coleman, Brianne
    Menard, Krista
    Yan, Jun
    Michaud, Erin
    Chang, Han
    Abdel-Hafiz, Hany A.
    Rozhok, Andrii, I
    Duex, Jason E.
    Agarwal, Neeraj
    Chauca-Diaz, Ana
    Johnson, Linda K.
    Ng, Terry L.
    Cambier, John C.
    Clambey, Eric T.
    Costello, James C.
    Korman, Alan J.
    Theodorescu, Dan
    SCIENCE ADVANCES, 2019, 5 (02)
  • [39] Anti-pancreatic tumor efficacy of a Listeria-based, Annexin A2-targeting immunotherapy in combination with anti-PD-1 antibodies
    Kim, Victoria M.
    Blair, Alex B.
    Lauer, Peter
    Foley, Kelly
    Che, Xu
    Soares, Kevin
    Xia, Tao
    Muth, Stephen T.
    Kleponis, Jennifer
    Armstrong, Todd D.
    Wolfgang, Christopher L.
    Jaffee, Elizabeth M.
    Brockstedt, Dirk
    Zheng, Lei
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2019, 7
  • [40] Association of BRCA1/2 pathogenic variants with primary tumor location and metastatic organotropism in pancreatic adenocarcinoma.
    Hood, Ryan
    Rathore, Srishti
    Seewald, Nicholas J.
    Reiss, Kim Anna
    JOURNAL OF CLINICAL ONCOLOGY, 2024, 42 (16)
12345