Assessment of inhalation flow patterns of soft mist inhaler co-prescribed with dry powder inhaler using inspiratory flow meter for multi inhalation devices

被引：31

作者：

Hira, Daiki ^{[1
,9
]}

Koide, Hiroyoshi ^{[2
]}

Nakamura, Shigemi ^{[3
]}

Okada, Toyoko ^{[3
]}

Ishizeki, Kazunori ^{[3
]}

Yamaguchi, Masafumi ^{[4
]}

Koshiyama, Setsuko ^{[5
]}

Oguma, Tetsuya ^{[6
]}

Ito, Kayoko ^{[7
]}

Funayama, Saori ^{[7
]}

Komase, Yuko ^{[8
]}

Morita, Shin-ya ^{[1
]}

Nishiguchi, Kohshi ^{[2
]}

Nakano, Yasutaka ^{[4
]}

Terada, Tomohiro ^{[1
]}

机构：

[1] Shiga Univ Med Sci Hosp, Dept Pharm, Otsu, Shiga, Japan

[2] Kyoto Pharmaceut Univ, Fac Pharmaceut Sci, Dept Clin Pharm, Kyoto, Kyoto, Japan

[3] Hitachi Automot Syst Ltd, Isesaki, Gunma, Japan

[4] Shiga Univ Med Sci, Dept Med, Div Resp Med, Otsu, Shiga, Japan

[5] Kinki Chozai Kadono Sanjo Pharm, Kyoto, Kyoto, Japan

[6] Oguma Family Clin, Kusatsu, Shiga, Japan

[7] Niigata Univ Med & Dent Hosp, Oral Rehabil, Niigata, Niigata, Japan

[8] St Marianna Univ, Yokohama City Seibu Hosp, Sch Med, Dept Resp Internal Med, Yokohama, Kanagawa, Japan

[9] Ritsumeikan Univ, Coll Pharmaceut Sci, Kusatsu, Shiga, Japan

来源：

PLOS ONE | 2018年 / 13卷 / 02期

关键词：

DRUG-DELIVERY; ELDERLY-PATIENTS; ADMIT SERIES; PERFORMANCE; THERAPY; ASTHMA; RATES; TURBUHALER; DESIGN; ISSUES;

D O I：

10.1371/journal.pone.0193082

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The patients' inhalation flow pattern is one of the significant determinants for clinical performance of inhalation therapy. However, the development of inhalation flow meters for various inhalation devices has been unable to keep up with the increasing number of newly launched inhalation devices. In the present study, we developed simple attachment orifices for the inhalation flow pattern monitoring system, which are suitable for all commercial inhalers, and investigated the efficacy of the system on the clinical inhalation instruction for patients co-prescribed dry powder inhaler (DPI) and soft mist inhaler (SMI). First, we constructed simple attachment orifices that were adjusted for 13 commercial inhalers, and examined the correlation between orifice and inhalation device. Second, the inhalation flow patterns (peak inspiratory flow rate, PIFR; inhalation duration time, DT) of patients prescribed a combination of DPI and SMI were monitored before and after inhalation instruction. The inhalation resistance of commercial inhalers are listed in the following order; Twincaps (R) > Handihaler (R) > Swinghaler (R) = Clickhaler (R) > Twisthaler (R) > Turbuhaler (R) > Jenuair (R) > Diskus (R) = Ellipta (R) > Diskhaler (R) > Breezhaler (R) > Respimat (R) = pMDI. The pressure drop via orifice was significantly correlated with that via the commercial inhaler. For the confirmation, all participants achieved the DPI criterion of PIFR. On the other hand, 4 participants (6 clinical visits) of 10 experimented participants could not achieve the essential criterion of DT (> 1.5 sec) for SMI, but all participants improved their duration time after inhalation instruction by pharmacists (P<0.05). In the present study, we successfully developed simple attachment orifice suitable for 13 commercial inhalation devices. These data suggested that our simple attachment orifices for the inhalation flow pattern monitoring system can detect patients with inadequate inhalation patterns via SMI.

引用

页数：12

共 22 条

[21] Improvement in the variation of inhalation properties of an FK888 dry powder inhaler using an E-haler, by adding coarse lactose in spherical soft agglomerates of fine drug particles, and its absorption in healthy volunteers
Nakate, T
Yoshida, H
Ohike, A
Tokunaga, Y
Ibuki, R
Kawashima, Y
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2005, 15 (02): : 167 - 175
[22] Remarks on the article "Effect of maximum inhalation flow and inhaled volume on formoterol drug deposition in-vitro from an Easyhaler dry-powder inhaler" by Abadelah, et al., volume 104, page 180-87 (2017)
Roberts, Daryl L.
Mitchell, Jolyon P.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2017, 109 : 144 - 145

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