U-shaped Gene Induced by Ecdysone Signal Pathway in Drosophila

The Drosophila U-shaped (ush) gene play important role in hemocyte differentiation. However, the mechanism of how the ush gene is mediated is still unclear. In this study, we reveals that ush gene expression increased during molting and metamorphosis stage of the third instar larva, 20-hydroxyecdysone (20E) treatment can up regulate ush expression, the silence of USP1 and EcR-A led to a reduced transcript level of ush gene in S2 cells. Those results indicated that the ecdysone signaling transduction pathway can mediate ush expression through its receptor.