Total synthesis of a marine imidazole alkaloid, clathridine A

被引：20

作者：

Ohta, S ^{[1
]}

Tsuno, N ^{[1
]}

Maeda, K ^{[1
]}

Nakamura, S ^{[1
]}

Taguchi, N ^{[1
]}

Yamashita, M ^{[1
]}

Kawasaki, I ^{[1
]}

机构：

[1] Kyoto Pharmaceut Univ, Kyoto 6078414, Japan

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 23期

关键词：

clathridine A; preclathridine A; marine alkaloid; total synthesis; parabanic acid; regioselective condensation; imidazole;

D O I：

10.1016/S0040-4039(00)00678-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first total synthesis of clathridine A (8), a marine imidazole alkaloid, was achieved by using a novel regioselective condensation as a key step, in which preclathridine A (2) was treated with 1-methylparabanic acid (11) in the presence of a silylating agent. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：4623 / 4627

页数：5

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