SYNTHESIS OF BENZOFURANS AND THEIR ANTIMICROBIAL AND ANTIINFLAMMATORY ACTIVITY

Ethyl benzofuran-2-carboxylate (1) was reacted with hydrazine hydrate (99%) to get benzofuran-2-carbohydrazide (2). Synthesis of [N'-(benzofuran-2-carbonyl)-hydrazino]-acetyl chlorides (3) was carried out by reacting chloroacetyl chloride with benzofuran-2-carbohydrazide 2. Refluxing thiourea in ethanol with compound (3) afforded benzofuran-2-carboxylic acid N'-(2-amino-thiazol-4-yL)-hydrazide (4), which was reacted with various aromatic aldehydes to form different Schiff's bases benzofuran-2-carboxylic acid N'-[2-(imino phenyl) thiazol-4-yl hydrazides (5a-j). In cold condition compound 5 were reacted with chloroacetyl chloride in presence of triethylamine to form benzofuran-2-carboxylic acid N'-[2-(3-chloro-2-oxo-4-phenyl-azetidin-1-yL) thiazol-4-yl hydrazides] (6a-j).