SYNTHESIS OF BENZOFURANS AND THEIR ANTIMICROBIAL AND ANTIINFLAMMATORY ACTIVITY

被引：0
|
作者：
Kumar, D. R. Harish [1 ]
Karvelkar, M. D. [1 ]
Das, Amit Kumar [1 ]
机构：
[1] Krupanidhi Coll Pharm, Dept Pharmaceut Chem, Bangalore 560035, Karnataka, India
来源：
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 2009年 / 19卷 / 02期
关键词：
DERIVATIVES; ANTIFUNGAL; POTENT; ACID;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Ethyl benzofuran-2-carboxylate (1) was reacted with hydrazine hydrate (99%) to get benzofuran-2-carbohydrazide (2). Synthesis of [N'-(benzofuran-2-carbonyl)-hydrazino]-acetyl chlorides (3) was carried out by reacting chloroacetyl chloride with benzofuran-2-carbohydrazide 2. Refluxing thiourea in ethanol with compound (3) afforded benzofuran-2-carboxylic acid N'-(2-amino-thiazol-4-yL)-hydrazide (4), which was reacted with various aromatic aldehydes to form different Schiff's bases benzofuran-2-carboxylic acid N'-[2-(imino phenyl) thiazol-4-yl hydrazides (5a-j). In cold condition compound 5 were reacted with chloroacetyl chloride in presence of triethylamine to form benzofuran-2-carboxylic acid N'-[2-(3-chloro-2-oxo-4-phenyl-azetidin-1-yL) thiazol-4-yl hydrazides] (6a-j).
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页码：133 / 136
页数：4
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