More than a bridging therapy: Targeting CD123 with rapidly switchable universal CAR-T cells for treatment of acute leukemia

被引:0
|
作者
Loff, Simon [1 ]
Meyer, Jan-Erik [2 ]
Spehr, Johannes [2 ]
Riewaldt, Julia [2 ]
Gruender, Cordula [1 ]
Schreiber, Maria [1 ]
Bachmann, Michael [3 ]
Pehl, Michael [1 ]
Ehninger, Gerhard [4 ]
Ehninger, Armin [1 ]
Cartellieri, Marc [2 ]
机构
[1] Gemoab Monoclonals GmbH, Dresden, Germany
[2] Cellex Patient Treatment GmbH, Dresden, Germany
[3] Helmholtz Zentrum Dresden Rossendorf eV, Dresden, Germany
[4] Cellex Gesell Zellgewinnung mbH, Dresden, Germany
关键词
D O I
10.1158/1538-7445.AM2020-4232
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
4232
引用
收藏
页数:2
相关论文
共 50 条
  • [41] Adoptive immunotherapy of acute myeloid leukemia (AML) with allogenic CAR t-cells targeting CD123.
    Galetto, Roman
    Lebuhotel, Celine
    Francon, Patricia
    Gouble, Agnes
    Smith, Julianne
    JOURNAL OF CLINICAL ONCOLOGY, 2015, 33 (15)
  • [42] Peptide-scFv Bispecific CAR-T Cells Targeting Acute Myeloid Leukemia
    Zoine, Jaquelyn T.
    Hebbar, Nikhil
    Moore, Sarah E.
    Langfitt, Deanna M.
    Ibanez, Jorge A.
    Talbot, Lindsay
    Krenciute, Giedre
    Gottschalk, Stephen
    Velasquez, M. Paulina
    MOLECULAR THERAPY, 2022, 30 (04) : 48 - 48
  • [43] Allogeneic TCRai3-deficient CAR T -cells targeting CD123 effectively eliminate myeloid leukemia cells in vitro and in vivo PDX mice
    Guzman, Monica L.
    Zong, Hongliang
    Sugita, Mayumi
    Lara-Martinez, Luis A.
    Bystrom, Laura M.
    Cruz, Nicole M.
    Galetto, Roman
    Gouble, Agnes
    Lebuhotel, Celine
    Bank, Alexander
    Smith, Julianne
    Roboz, Gail J.
    CANCER RESEARCH, 2016, 76
  • [44] SS30, a novel thioaptamer targeting CD123, inhibits the growth of acute myeloid leukemia cells
    Wang, Meng
    Wu, Haibin
    Duan, Mingyue
    Yang, Ying
    Wang, Guoxia
    Che, Fengyu
    Liu, Bailing
    He, Wei
    Li, Qiao
    Zhang, Liyu
    LIFE SCIENCES, 2019, 232
  • [45] Expansion kinetics and cytokine profiles of UniCAR-T-CD123, a rapidly switchable two-component CAR-T therapy, in patients with relapsed/refractory AML.
    Ehninger, Armin
    Riewaldt, Julia
    Gruender, Cordula
    Franke, Kristin
    Schreiber, Maria
    Wermke, Martin
    Kraus, Sabrina
    Kreissig, Carla
    Koedam, Jan
    Pehl, Michael
    Ehninger, Gerhard
    Cartellieri, Marc
    CANCER RESEARCH, 2021, 81 (13)
  • [46] Emerging learnings in cell therapy: novel binding domains, universal CAR-T cells, and more
    Rotte, Anand
    FRONTIERS IN ONCOLOGY, 2024, 14
  • [47] Tandem bispecific CD123/CLL-1 CAR-T cells exhibit specific cytolytic effector functions against human acute myeloid leukaemia
    Wang, Xiang-Yu
    Bian, Mei-Ru
    Lin, Guo-Qiang
    Yu, Lei
    Zhang, Yan-Ming
    Wu, De-Pei
    EUROPEAN JOURNAL OF HAEMATOLOGY, 2024, 112 (01) : 83 - 93
  • [48] CAR-T cells dual-target CD123 and NKG2DLs to eradicate AML cells and selectively target immunosuppressive cells
    Jin, Xin
    Xie, Danni
    Sun, Rui
    Lu, Wenyi
    Xiao, Xia
    Yu, Yibing
    Meng, Juanxia
    Zhao, Mingfeng
    ONCOIMMUNOLOGY, 2023, 12 (01):
  • [49] CAR-T cells targeting CLL-1 as an approach to treat acute myeloid leukemia
    Jinghua Wang
    Siyu Chen
    Wei Xiao
    Wende Li
    Liang Wang
    Shuo Yang
    Weida Wang
    Liping Xu
    Shuangye Liao
    Wenjian Liu
    Yang Wang
    Nawei Liu
    Jianeng Zhang
    Xiaojun Xia
    Tiebang Kang
    Gong Chen
    Xiuyu Cai
    Han Yang
    Xing Zhang
    Yue Lu
    Penghui Zhou
    Journal of Hematology & Oncology, 11
  • [50] CAR-T cells targeting CLL-1 as an approach to treat acute myeloid leukemia
    Wang, Jinghua
    Chen, Siyu
    Xiao, Wei
    Li, Wende
    Wang, Liang
    Yang, Shuo
    Wang, Weida
    Xu, Liping
    Liao, Shuangye
    Liu, Wenjian
    Wang, Yang
    Liu, Nawei
    Zhang, Jianeng
    Xia, Xiaojun
    Kang, Tiebang
    Chen, Gong
    Cai, Xiuyu
    Yang, Han
    Zhang, Xing
    Lu, Yue
    Zhou, Penghui
    JOURNAL OF HEMATOLOGY & ONCOLOGY, 2018, 11