Characterization of the phosphodiesterase 10A (PDE10A) PET tracer [11C]MK-8193 in monkey and rat

被引：0

作者：

Hostetler, Eric ^{[1
]}

Joshi, Aniket ^{[1
]}

Zeng Zhizhen ^{[1
]}

Fan Hong ^{[1
]}

Eng, Waisi ^{[1
]}

Purcell, Mona ^{[1
]}

Daneker, Lori ^{[1
]}

Gantert, Liza ^{[1
]}

Meng Jun ^{[1
]}

O'Malley, Stacey ^{[1
]}

Chen Tsing-Bau ^{[1
]}

Williams, Mangay ^{[1
]}

Riffel, Kerry ^{[1
]}

Smith, Sean ^{[2
]}

Flores, Broc ^{[3
]}

Raheem, Izzat ^{[3
]}

Cox, Chris ^{[3
]}

Coleman, Paul ^{[3
]}

Cook, Jacquelynn ^{[1
]}

Evelhoch, Jeff ^{[1
]}

机构：

[1] Merck & Co Inc, Imaging, West Point, PA USA

[2] Merck & Co Inc, Neurosci, West Point, PA USA

[3] Merck & Co Inc, Med Chem, West Point, PA USA

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2013年 / 56卷

关键词：

D O I：

暂无

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

P230

引用

页码：S317 / S317

页数：1

共 50 条

[21] Phosphodiesterase 10A in Schizophrenia: A PET Study Using [11C]IMA107
Marques, Tiago Reis
Natesan, Sridhar
Niccolini, Flavia
Politis, Marios
Gunn, Roger N.
Searle, Graham E.
Howes, Oliver
Rabiner, Eugenii A.
Kapur, Shitij
AMERICAN JOURNAL OF PSYCHIATRY, 2016, 173 (07): : 714 - 721
[22] Kinetic analysis of [11C]-IMA107, a novel PET radiotracer for PDE10A
Searle, Graham
Marques, Tiago Reis
Plisson, Christophe
Natesan, Sridhar
Howes, Oliver
Tzortzi, Andri
Passchier, Jan
Kapur, Shitij
Gunn, Roger
Rabiner, Eugenii
JOURNAL OF NUCLEAR MEDICINE, 2014, 55
[23] Novel benzimidazole derivatives as phosphodiesterase 10A (PDE10A) inhibitors with improved metabolic stability
Chino, Ayaka
Masuda, Naoyuki
Amano, Yasushi
Honbou, Kazuya
Mihara, Takuma
Yamazaki, Mayako
Tomishima, Masaki
BIOORGANIC & MEDICINAL CHEMISTRY, 2014, 22 (13) : 3515 - 3526
[24] Benzothiophene derivatives as phosphodiesterase 10A (PDE10A) inhibitors: Hit-to-lead studies
Kawamoto, Yoshito
Tomino, Minako
Hiramatsu, Kenichi
Oyama, Yoshiaki
Hayashi, Yasuhiro
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2019, 29 (11) : 1419 - 1422
[25] Characterization of [11C]Lu AE92686 as a PET radioligand for phosphodiesterase 10A in the nonhuman primate brain
Yang, Kai-Chun
Stepanov, Vladimir
Amini, Nahid
Martinsson, Stefan
Takano, Akihiro
Nielsen, Jacob
Bundgaard, Christoffer
Bang-Andersen, Benny
Grimwood, Sarah
Halldin, Christer
Farde, Lars
Finnema, Sjoerd J.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2017, 44 (02) : 308 - 320
[26] Characterization of [11C]Lu AE92686 as a PET radioligand for phosphodiesterase 10A in the nonhuman primate brain
Kai-Chun Yang
Vladimir Stepanov
Nahid Amini
Stefan Martinsson
Akihiro Takano
Jacob Nielsen
Christoffer Bundgaard
Benny Bang-Andersen
Sarah Grimwood
Christer Halldin
Lars Farde
Sjoerd J. Finnema
European Journal of Nuclear Medicine and Molecular Imaging, 2017, 44 : 308 - 320
[27] Synthesis of Fluorine-Containing Phosphodiesterase 10A (PDE10A) Inhibitors and the In Vivo Evaluation of F-18 Labeled PDE10A PET Tracers in Rodent and Nonhuman Primate
Li, Junfeng
Zhang, Xiang
Jin, Hongjun
Fan, Jinda
Flores, Hubert
Perlmutter, Joel S.
Tu, Zhude
JOURNAL OF MEDICINAL CHEMISTRY, 2015, 58 (21) : 8584 - 8600
[28] A human [11C]T-773 PET study of PDE10A binding after oral administration of TAK-063, a PDE10A inhibitor
Takano, Akihiro
Stenkrona, Per
Stepanov, Vladimir
Amini, Nahid
Martinsson, Stefan
Tsai, Max
Goldsmith, Paul
Xie, Jinhui
Wu, Jingtao
Uz, Tolga
Halldin, Christer
Macek, Thomas A.
NEUROIMAGE, 2016, 141 : 10 - 17
[29] Medicinal chemistry strategies for the development of phosphodiesterase 10A (PDE10A) inhibitors - An update of recent progress
Amin, Harsh S.
Parikh, Palak K.
Ghate, Manjunath D.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 214
[30] N-Methylanilide and N-methylbenzamide derivatives as phosphodiesterase 10A (PDE10A) inhibitors
Kilburn, John Paul
Kehler, Jan
Langgard, Morten
Erichsen, Mette N.
Leth-Petersen, Sebastian
Larsen, Mogens
Christoffersen, Claus Tornby
Nielsen, Jacob
BIOORGANIC & MEDICINAL CHEMISTRY, 2013, 21 (19) : 6053 - 6062

← 1 2 3 4 5 →