Characterization of the phosphodiesterase 10A (PDE10A) PET tracer [11C]MK-8193 in monkey and rat

被引：0
|
作者：
Hostetler, Eric [1 ]
Joshi, Aniket [1 ]
Zeng Zhizhen [1 ]
Fan Hong [1 ]
Eng, Waisi [1 ]
Purcell, Mona [1 ]
Daneker, Lori [1 ]
Gantert, Liza [1 ]
Meng Jun [1 ]
O'Malley, Stacey [1 ]
Chen Tsing-Bau [1 ]
Williams, Mangay [1 ]
Riffel, Kerry [1 ]
Smith, Sean [2 ]
Flores, Broc [3 ]
Raheem, Izzat [3 ]
Cox, Chris [3 ]
Coleman, Paul [3 ]
Cook, Jacquelynn [1 ]
Evelhoch, Jeff [1 ]
机构：
[1] Merck & Co Inc, Imaging, West Point, PA USA
[2] Merck & Co Inc, Neurosci, West Point, PA USA
[3] Merck & Co Inc, Med Chem, West Point, PA USA
来源：
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2013年 / 56卷
关键词：
D O I：
暂无
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
P230
引用
收藏
页码：S317 / S317
页数：1
相关论文
共 50 条
  • [1] Preclinical Characterization of the Phosphodiesterase 10A PET Tracer [11C]MK-8193
    Hostetler, Eric D.
    Fan, Hong
    Joshi, Aniket D.
    Zeng, Zhizhen
    Eng, Waisi
    Gantert, Liza
    Holahan, Marie
    Meng, Xianjun
    Miller, Patricia
    O'Malley, Stacey
    Purcell, Mona
    Riffel, Kerry
    Salinas, Cristian
    Williams, Mangay
    Ma, Bennett
    Buist, Nicole
    Smith, Sean M.
    Coleman, Paul J.
    Cox, Christopher D.
    Flores, Brock A.
    Raheem, Izzat T.
    Cook, Jacquelynn J.
    Evelhoch, Jeffrey L.
    MOLECULAR IMAGING AND BIOLOGY, 2016, 18 (04) : 579 - 587
  • [2] Preclinical Characterization of the Phosphodiesterase 10A PET Tracer [11C]MK-8193
    Eric D. Hostetler
    Hong Fan
    Aniket D. Joshi
    Zhizhen Zeng
    Waisi Eng
    Liza Gantert
    Marie Holahan
    Xianjun Meng
    Patricia Miller
    Stacey O’Malley
    Mona Purcell
    Kerry Riffel
    Cristian Salinas
    Mangay Williams
    Bennett Ma
    Nicole Buist
    Sean M. Smith
    Paul J. Coleman
    Christopher D. Cox
    Brock A. Flores
    Izzat T. Raheem
    Jacquelynn J. Cook
    Jeffrey L. Evelhoch
    Molecular Imaging and Biology, 2016, 18 : 579 - 587
  • [3] Discovery of [11C]MK-8193 as a PET tracer to measure target engagement of phosphodiesterase 10A (PDE10A) inhibitors
    Cox, Christopher D.
    Hostetler, Eric D.
    Flores, Broc A.
    Evelhoch, Jeffrey L.
    Fan, Hong
    Gantert, Liza
    Holahan, Marie
    Eng, Waisi
    Joshi, Aniket
    McGaughey, Georgia
    Meng, Xiangjun
    Purcell, Mona
    Raheem, Izzat T.
    Riffel, Kerry
    Yan, Youwei
    Renger, John J.
    Smith, Sean M.
    Coleman, Paul J.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2015, 25 (21) : 4893 - 4898
  • [4] 11C-MP-10 is a suitable radiotracer for PET imaging of phosphodiesterase 10A (PDE10A)
    Lin, Shu-fei
    Labaree, David
    Chen, Ming-Kai
    Holden, Daniel
    Kapinos, Michael
    Teng, Jo-ku
    Najafzadeh, Soheila
    Carson, Richard
    Huang, Yiyun
    JOURNAL OF NUCLEAR MEDICINE, 2014, 55
  • [5] Discovery of Phosphodiesterase 10A (PDE10A) PET Tracer AMG 580 to Support Clinical Studies
    Hu, Essa
    Chen, Ning
    Kunz, Roxanne K.
    Hwang, Dah-Ren
    Michelsen, Klaus
    Davis, Carl
    Ma, Ji
    Shi, Jianxia
    Lester-Zeiner, Dianna
    Hungate, Randall
    Treanor, James
    Chen, Hang
    Allen, Jennifer R.
    ACS MEDICINAL CHEMISTRY LETTERS, 2016, 7 (07): : 719 - 723
  • [6] Development of a positron emission tomography (PET) tracer to evaluate phosphodiesterase 10A (PDE10A) target engagement
    Chappell, Mark
    Tripp, Allie
    Bender, David
    Benesh, Dana
    Monk, Scott
    Chernet, Eyassu
    Rash, Karen
    Phebus, Lee
    Slieker, Lawrence
    Kuwabara, Hiroto
    Dannals, Robert
    Valentine, Heather
    Ravert, Hayden
    Wong, Dean
    Barth, Vanessa
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2016, 251
  • [7] Rapid Identification of a Novel Small Molecule Phosphodiesterase 10A (PDE10A) Tracer
    Hu, Essa
    Ma, Ji
    Biorn, Christopher
    Lester-Zeiner, Dianna
    Cho, Robert
    Rumfelt, Shannon
    Kunz, Roxanne K.
    Nixey, Thomas
    Michelsen, Klaus
    Miller, Silke
    Shi, Jianxia
    Wong, Jamie
    Della Puppa, Geraldine Hill
    Able, Jessica
    Talreja, Santosh
    Hwang, Dah-Ren
    Hitchcock, Stephen A.
    Porter, Amy
    Immke, David
    Allen, Jennifer R.
    Treanor, James
    Chen, Hang
    JOURNAL OF MEDICINAL CHEMISTRY, 2012, 55 (10) : 4776 - 4787
  • [8] Phosphodiesterase 10A (PDE10A) and psychosis: Studies using the PDE10A inhibitor papaverine and PDE10A knockout mice
    Siuciak, JA
    Chapin, DS
    McCarthy, SA
    SCHIZOPHRENIA BULLETIN, 2005, 31 (02) : 310 - 310
  • [9] CHARACTERIZATION OF [11C]LU AE92686 AS A PHOSPHODIESTERASE 10A PET RADIOLIGAND IN THE MONKEY BRAIN
    Yang, K. C.
    Stepanov, V.
    Amini, N.
    Martinsson, S.
    Takano, A.
    Nielsen, J.
    Bang-Andersen, B.
    Grimwood, S.
    Halldin, C.
    Farde, L.
    Finnema, S. J.
    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2016, 36 : 618 - 619
  • [10] Current Landscape of Phosphodiesterase 10A (PDE10A) Inhibition
    Chappie, Thomas A.
    Helal, Christopher J.
    Hou, Xinjun
    JOURNAL OF MEDICINAL CHEMISTRY, 2012, 55 (17) : 7299 - 7331
12345